DL-alpha-Hydrazino-delta-aminovaleric acid (DL-HAVA) is a potent and fairly specific inhibitor of ornithine decarboxylase (EC 4.1.1.17). Its effect on polyamine metabolism and cell proliferation was investigated in sarcoma-180, inoculated into the axillary region of mice. In the tumor tissues, the
Repeated intraperitoneal and intratumor administration of polyhexamethylene guanidine (PMG) in 3 and 5 mg/kg doses to sarcoma 180 bearing mice caused a significant reduction in tumour mass accompanied by increased incidence of diploid and hypodiploid cells. PMG brings about an increase in the number
We used molecular cloning to isolate a functional gene for mouse ornithine decarboxylase (OrnDCase; L-ornithine carboxy-lyase, EC 4.1.1.17) from a cell line in which that gene had been selectively amplified. The position of the 5' terminus of the mRNA was identified, and the coding sequence was
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