leukopenia/carbohydrate

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Effects of endotoxaemia and carbohydrate overload on glucose and insulin dynamics and the development of laminitis in horses.

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BACKGROUND Insulin resistance (IR) is a risk factor for pasture-associated laminitis in equids and alimentary carbohydrate overload may trigger laminitis. Whether glucose metabolism responses to carbohydrate overload are more pronounced in insulin-resistant horses requires further

Disparate effects of LPS infusion and carbohydrate overload on inflammatory gene expression in equine laminae.

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Although clinical evidence of endotoxemia has been associated with the development of acute laminitis in hospitalized horses with gastrointestinal diseases and endotoxins have been detected in the circulation of horses with experimentally-induced laminitis, it is unclear what role, if any,

Profound changes in blood parameters during torpor in a South American marsupial.

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Seasonal torpor or hibernation is a phenomenon characterized by a physiological transition to dormancy (torpor) during challenging periods in terms of energy availability or metabolic load. Extensive physiological reprogramming and changes in gene-expression, immune function, oxygen transport and

Treatment with an oral fluoropyrimidine, S-1, plus cisplatin in patients who failed postoperative gemcitabine treatment for pancreatic cancer: a pilot study.

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BACKGROUND This study set out to evaluate, in patients with gemcitabine-resistant pancreatic cancer, the response rate and toxicity of S-1 plus cisplatin (CDDP). METHODS Seventeen patients with histologically diagnosed invasive ductal pancreatic cancer were enrolled in this study. All patients had

Some structural and biological properties of Brucella endotoxin.

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Hot phenol-water extraction of smooth Brucella abortus and B. melitensis cells yielded a toxic fraction which was recovered from the phenol phase (fraction 5). Chemically, fractions 5 from both Brucella species were lipid-carbohydrate-protein-2 keto-3-deoxyoctulosonic acid complexes which were

[Haematological features of anorexia nervosa (author's transl)].

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Nine patients with anorexia nervosa were studied, who had varying degrees of bone marrow failure ranging from a slight neutropenia to severe pancytopenia. In addition to routine laboratory work bone marrow biopsies were performed at admission and during the course of disease. In four of those

Characterization of endotoxin from the rumen bacterium Megasphaera elsdenii.

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Phenol-water extraction of Megasphaera elsdenii, a predominant gram-negative coccus in rumens of cattle fed high-grain diets, yielded material that exhibited typical characteristics of endotoxin. The extract was lethal to mice and to chicken embryos, caused biphasic fever in rabbits, leukopenia in

Determinants of the biologic activity of surface slime in experimental Pseudomonas aeruginosa infections.

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A purified fraction of the extracellular slime of Pseudomonas aeruginosa, characterized chemically as a glycolipoprotein (GLP), has been identified as responsible for a number of biologic properties of the viable cell. Mice immunized actively or passively against GLP are protected against an

Repeated dose toxicity study (28 days) in rats and mice with N-methylpyrrolidone (NMP).

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Twenty-eight day feeding studies were conducted to evaluate the repeated dose toxicity of NMP, a widely used industrial solvent, in Crl:CD BR rats and B6C3F1 mice. Groups of 5 male and 5 female rats each were fed either 0, 2,000, 6,000, 18,000, or 30,000 ppm NMP; similar groups of mice were fed

Long-term progression-free survival in a metastatic pancreatic cancer patient treated with first-line nab-paclitaxel and gemcitabine.

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BACKGROUND Prognosis of patients with metastatic pancreatic cancer is dismal. Recently, two first-line combination chemotherapy regimens have shown a survival benefit over single-agent gemcitabine. METHODS A 57-year old metastatic pancreatic cancer patient from our department (Eastern Cooperative

Prognostic factors in japanese patients with advanced pancreatic cancer treated with single-agent gemcitabine as first-line therapy.

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OBJECTIVE The purpose of the retrospective analysis is to elucidate the treatment efficacy and toxicity as well as to identify prognostic factors in Japanese patients with advanced pancreatic cancer treated with gemcitabine. METHODS Two hundred and sixty-four patients with pathologically confirmed

A randomized phase 3 trial comparing pemetrexed/carboplatin and docetaxel/carboplatin as first-line treatment for advanced, nonsquamous non-small cell lung cancer.

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BACKGROUND This study compared survival without toxicity in patients with advanced, nonsquamous non-small cell lung cancer who were treated with first-line pemetrexed/carboplatin or docetaxel/carboplatin. METHODS This multicenter, open-label, parallel-group, phase 3 trial comprised patients

Recombinant Granulocyte-Macrophage Colony-Stimulating Factor (rGM-CSF) : A Review of its Pharmacological Properties and Prospective Role in the Management of Myelosuppression.

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CONCLUSIONS Recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) is a polypeptide hormone produced through recombinant DNA technologies in glycosylated (yeast or mammalian expression systems) or nonglycosylated (Escherichia coli expression system) form. It is a multilineage

Oral capecitabine in gemcitabine-pretreated patients with advanced pancreatic cancer.

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OBJECTIVE To date, no standard regimen for salvage chemotherapy after gemcitabine (Gem) failure has been defined for patients with advanced pancreatic cancer (PC). Oral capecitabine (Cap) has shown promising activity in first-line chemotherapy trials in PC patients. METHODS Within a prospective

Polysaccharide of the slime glycolipoprotein of Pseudomonas aeruginosa.

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The polysaccharide moiety was isolated by mild acid hydrolysis from the slime glycolipoprotein of Pseudomonas aeruginosa strain BI. After gel filtration, the polysaccharide obtained from the Carbohydrate peak fractions was found to be lipid- and protein-free. Analyses indicated that the

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