Anrotenil hydrochloride capsule was used to treat soft tissue sarcomas with first-line chemotherapy failure (doxorubicin + ifosfamide). Oral administration was conducted on an empty stomach before breakfast (12mg), and the drug was discontinued for 2 weeks for one week (3 weeks for one cycle) until the disease progressed or became intolerable.

Soft Tissue Sarcomas

The standard first-line chemotherapy regimen (adriamycin + ifosfamide) failed

Anlotinib Hydrochloride

Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital

Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule

There are and only 50% of individuals who survive this time

The percentage of patients whose tumors have shrunk to a certain amount of time and stayed that way for a certain amount of time

In order to better conduct clinical studies and ensure the prospective and timeliness of the studies, patients' IPD will be kept confidential.

YaoWeitao

Chief physician

Henan Cancer Hospital

Patients with locally advanced and unresectable or metastatic sarcoma will receive MGCD516 at the discretion of the principal investigator until disease progression, unacceptable toxicity or adverse event(s) or withdrawal of consent.

Liposarcoma

Metastatic Liposarcoma

Administered at 150 mg orally, daily, in continuous 21 day cycles. An orally available, potent small molecular inhibitor of several related receptor tyrosine kinases.

MGCD516

Massachussetts General Hospital

Washington University

Columbia University Irving Medical Center

Sitravatinib in Advanced Liposarcoma and Other Soft Tissue Sarcomas

A Phase II Trial of Sitravatinib (MGCD516), a Multi-receptor Tyrosine Kinase Inhibitor, in Advanced Liposarcoma and Other Soft Tissue Sarcomas

To assess the efficacy of MGCD516 in patients with advanced liposarcoma by evaluating the progression free rate at 12 weeks as compared historical controls.

To evaluate the safety profile of MGCD516.

To assess the efficacy of MGCD516 in patients with advanced liposarcoma.

liposarcoma/tyrosine

Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule

Sitravatinib in Advanced Liposarcoma and Other Soft Tissue Sarcomas

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم