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الصفحة 1 من عند 104 النتائج
Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
RELATED APPLICATIONS
This application claims the priority benefit of U.S. Ser. No. 10/777,893, filed Feb. 12, 2004 (now U.S. Pat. No. 7,300,753), and PCT/US04/21670 filed Jul. 7, 2004.
FIELD OF THE INVENTION
The invention relates generally to antibodies and peptide reagents for the detection of
6-(2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazin-7-yl)-N-(4-morpholinophenyl)im- idazo[1,2-a] pyrazin-8-amine as a spleen tyrosine kinase inhibitor
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
Not Applicable.
THE NAMES OF PARTIES TO A JOINT RESEARCH AGREEMENT
Not Applicable
INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ON A COMPACT DISC
Not Applicable
BACKGROUND OF THE INVENTION
(1) Field of the Invention
(2) Description
Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
This invention relates to compounds. More specifically, the invention relates to compounds useful as kinase inhibitors, along with processes to prepare the compounds and uses of the compounds. Specifically, the invention relates to inhibitors of Bruton's tyrosine kinase (BTK).
BACKGROUND
Kinases are
Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
RELATED APPLICATIONS
This application is a national phase filing under 35 U.S.C. 371 of International Application No. PCT/GB2015/051719, filed Jun. 11, 2015, which claims the benefit of and priority to United Kingdom Patent Application No. GB1410430.1, filed Jun. 11, 2014, the contents of which
Tyrosine kinase inhibitors
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION
The present disclosure relates to the field of tyrosine kinase enzyme inhibition, in particular anaplastic lymphoma kinase (ALK) inhibition using novel small molecules. Provided are compounds capable to modulate ALK activity, compositions that comprise the compounds, and
Tyrosine kinase inhibitors
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION
The present disclosure relates to the field of tyrosine kinase enzyme inhibition, in particular anaplastic lymphoma kinase (ALK) inhibition using novel small molecules. Provided are compounds capable to modulate ALK activity, compositions that comprise the compounds, and
Human ALK protein tyrosine kinase
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to the field of molecular genetics of cancer. Specifically, the present invention relates to human lymphomas in which a translocation between chromosomes 2 and 5 (referred to in the art as "t(2;5)") has occurred.
Combination of an anti-CD19 antibody and a Bruton's tyrosine kinase inhibitor and uses thereof
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
This patent application is the U.S. National Stage of International Application No. PCT/EP2016/061744 filed May 25, 2016, which claims the benefit of EP 15196860.9 filed Nov. 27, 2015 and EP 15169124.3 filed May 26, 2015, each of which is incorporated by reference in its entirety.
FIELD OF THE
Antibodies for recognition of alk protein tyrosine/kinase receptor
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to the field of molecular genetics of cancer. Specifically, the present invention relates to human lymphomas in which a translocation between chromosomes 2 and 5 (referred to in the art as "t(2;5)") has occurred.
Compositions for detecting mutant anaplastic lymphoma kinase in lung cancer
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION
The invention relates generally to proteins and genes involved in cancer, and to the detection, diagnosis and treatment of cancer.
BACKGROUND OF THE INVENTION
Many cancers are characterized by disruptions in cellular signaling pathways that lead to aberrant control of cellular
Methods of treating lung cancer using inhibitors anaplastic lymphoma kinase
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION
The invention relates generally to proteins and genes involved in cancer, and to the detection, diagnosis and treatment of cancer.
BACKGROUND OF THE INVENTION
Many cancers are characterized by disruptions in cellular signaling pathways that lead to aberrant control of cellular
Bruton's tyrosine kinase inhibitors
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
BACKGROUND
Signaling through the B-cell receptor (BCR) can lead to a range of biological outputs depending upon, in part, the developmental stage of the B-cell. Faulty signaling through the BCR can cause disregulation of the B-cell function and/or the formation of auto-antibodies which may lead to
Inhibitors of Bruton's tyrosine kinase
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
BACKGROUND OF THE INVENTION
Bruton's
Inhibitors of Bruton's tyrosine kinase
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
BACKGROUND OF THE INVENTION
Bruton's
Inhibitors of Bruton's tyrosine kinase
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
BACKGROUND OF THE INVENTION
Bruton's
قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم
- يعمل في 55 لغة
- العلاجات العشبية مدعومة بالعلم
- التعرف على الأعشاب بالصورة
- خريطة GPS تفاعلية - ضع علامة على الأعشاب في الموقع (قريبًا)
- اقرأ المنشورات العلمية المتعلقة ببحثك
- البحث عن الأعشاب الطبية من آثارها
- نظّم اهتماماتك وابقَ على اطلاع دائم بأبحاث الأخبار والتجارب السريرية وبراءات الاختراع
اكتب أحد الأعراض أو المرض واقرأ عن الأعشاب التي قد تساعد ، واكتب عشبًا واطلع على الأمراض والأعراض التي تستخدم ضدها.
* تستند جميع المعلومات إلى البحوث العلمية المنشورة
