Group A: It was the control group. Participants were advised to start taking placebo capsule of Zinc in a look alike preparation on their first day of chemo-radiotherapy and continued taking it a month after their chemo-radiotherapy ended

Group B: Cap zinc 220 mg (equivalent to 50 mg of elemental zinc) on 1st day of their chemo-radiotherapy and continued taking it a month after their chemo-radiotherapy ended.

Taste, Altered

Look alike cap of corn starch as a placebo of Zinc to be given on day 1 of chemo-radiotherapy

Placebo oral Zinc capsule

Zinc sulfate in test group dose was 220 mg which is equivalent to 50 mg of elemental zinc

Zinc Sulfate 220 MG

Dow University of Health Sciences

Efficacy of Zinc on Concurrent Chemo-radiotherapy Induced Taste Alterations

Efficacy of Zinc Sulfate on Concurrent Chemoradiotherapy Induced Taste Alterations in Oral Cancer Patients- A Double Blind Randomized Controlled Trial

Every participant's taste acuity was by detection and recognition using different concentrations of taste solutions. The solutions were prepared in accordance with the International Standard Organization 3972:2011/Cor 1:2012 which provides guidelines for Method of investigating of taste sensitivity. Sodium chloride was used as a stimulus for salty, sucrose for sweet, citric acid for sour and caffeine for bitter. Detection threshold was the minimum concentration at which the subject can detect that there is something different from water, but may not identify its quality. Recognition threshold was considered as the lowest level of a solution at which a subject can correctly recognize its taste.

Asma Hayat Khan

Post Graduate Trainee

Each patient was asked to pick one of the sealed envelopes from a box. The sealed envelopes contained either alphabets A or B. The sealed envelopes were blinded to both the investigator and the patient. The generation of random allocation sequence and assignment of participants to intervention were done by the principal investigator.
Both the investigator and the patient were blinded (double-blinded) about the groups and intervention.

manganese/تسوس سني

Efficacy of Zinc on Concurrent Chemo-radiotherapy Induced Taste Alterations

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم