Analgesia

Evaluation and comparison between perianal block and caudal block in its efficacy, side effects, and postoperative pain relieve, among pediatrics patient undergoing trans-anal pull through in congenital megacolon (Hirschsprung's disease).

Peri-anal local anaesthetic infiltration

Peri-anal Local Anaesthetic Infiltration Versus Caudal Anaesthesia in Hirschsprung's Disease.

Peri-anal Local Anaesthetic Infiltration Versus Caudal Anaesthesia for Post-operative Pain Relief in Trans-anal Pull Through Operation for Hirschsprung's Disease.

Evaluation of post-operative pain relieve between perianal block and caudal block by using FLACC score.

Mohamed Salah Rashed Abd Elraheem

Principal Investigator

Assiut University

Patients diagnosed with CDI during 2017 in the University Hospital 12 de Octubre will be systematically evaluated by an Infectious Disease expert to ensure compliance with clinical practice guidelines about specific treatment for CDI, depending on the severity of the episode and the existence of previous episodes. This group of patients will also receive a close follow up during the period of greatest risk of relapse (8 weeks after completion of antibiotic treatment for CDI) in order to reduce as far as possible, the number of relapses.

Patients diagnosed with CDI during 2015 in the University Hospital 12 de Octubre in which a systematic intervention was not done.

As patients with CDI are going to be prospectively followed, apart from the routine hematology and biochemistry analysis, serum immunoglobulin levels, serum complement levels (C3 and C4) and peripheral blood lymphocyte subpopulations will be measured at the end of CDI treatment. The levels of these immunological parameters will be tested as markers for relapse by retrospectively comparing them between patients with and without recurrence. A stool sample will be collected at the end of treatment to evaluate predictors of bad outcome or recurrence: Inflammatory markers (lactoferrin, calprotectin, IL-10) We will retrospectively compare these parameters between patients with and without recurrence.

Clostridium Difficile

Enterocolitis, Pseudomembranous

Specific "bundle" of measures:
Systematic evaluation of all patients diagnosed with CDI by an Infectious Disease expert To ensure compliance with clinical practice guidelines about specific treatment for CDI, depending on the severity of the episode and the existence of previous episodes and to optimize concomitant antibiotic therapy ("antimicrobial stewardship").
To ensure appropriate monitoring during the period of greatest risk of relapse in order to reduce as far as possible, the number of relapses. Personalized assistance by telephone or by email for early consultation in case of recurrence of symptoms or need for a new antibiotic course.

Systematic evaluation by an ID expert.

Unidad de Enfermedades Infecciosas. Hospital Universitario 12 de Octubre

Antimicrobial Stewardship Program for Clostridium Difficile Infection.

Antimicrobial Stewardship Program Based on the Detection and Monitoring of Patients With Clostridium Difficile Infection (PACTA-ICD)

Number of recurrences in each group within the following 8 weeks after the end of specific treatment for the initial Clostridium difficile infection episode.

Percentage of compliance with clinical practice guidelines (European Society of Clinical Microbiology and Infectious Diseases, 2013) for CDI treatment.

Percentage of patients with antibiotic treatments removed or adjusted as a result of the diagnosis of CDI.

Percentage of patients who die within 72 hours of the Clostridium difficile infection diagnosis.

Percentage of patients who die within 3 months of the Clostridium difficile infection diagnosis.

José María Aguado García, MD, PhD

Hospital Universitario 12 de Octubre

Merck Sharp & Dohme Corp.

Fortrans (split dose) + Mentholyptus drops

Bowel Cleansing in Preparation for Colonoscopy

preparation cleaning solution

American University of Beirut Medical Center

PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation

PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation: A Randomised Controlled Study

Superiority of Fortrans + Halls to MoviPrep in cleansing the bowels

megacolon/غثيان

Peri-anal Local Anaesthetic Infiltration Versus Caudal Anaesthesia in Hirschsprung's Disease.

Antimicrobial Stewardship Program for Clostridium Difficile Infection.

PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم