Participants will be on routine HAART only. No Artemisia Annua, Moringa oleifera will be given.

Participants will be given HAART and Artemisia annua leaf powder 4 g per day. They will only receive Artemisia Annua, Moringa oleifera will not be given.

Participants will be given HAART with Artemisia annua leaf powder of 4 grams per day and Moringa oleifera leaf powder of 10 grams per day. Both Artemisia Annua, Moringa oleifera will be given.

HIV Infections

Artemisia Annua, Moringa oleifera

Mbarara Regional Referral Hospital

Evaluation of Artemisia Annua and Moringa

EVALUATION OF THE EFFECT OF ARTEMISIA ANNUA AND MORINGA OLEIFERA ON IMMUNOLOGICAL RESPONSE IN HAART HIV PATIENTS at MRRH

The primary outcome will be change in CD4 counts (absolute and relative) at 6 and 12 months in study participants following enrollment in the study.

Viral load at baseline, 6 and 12 months from time of initiating herbal treatment with the above mentioned herbs.

Complete Blood Count at baseline, 6 and 12 months

Immunoglobins (E, A, G) associated with HIV infections in HAART patients at baseline, 6 and 12 months

Antiretroviral plasma drug level in HAART patients at baseline and after one and two weeks

Liver function biomarkers at baseline, six and twelve months

Incidence of side effects or adverse drug reactions in the study participants over the study period

Renal function biomarkers at baseline, six and twelve months

Participant lab results will be availed to the attending physician

Mbarara University of Science and Technology

ANAMED

Participants will be stratified according to baseline CD4 levels: 350 - 250, 249 - 150, below 149. Computer generated numbers will be used to assign selected participants into study groups using simple randomization method to either control group with HAART only, or HAART with Artemisia annua group or HAART with Artemisia annua and Moringa oleifera group of 1:1:1.

Two research assistants will be recruited and trained as observers and data collectors to increase accuracy and consistency in documenting the needed data. They will be assisted by the HIV clinic staff and these research assistants will be blinded to the hypotheses of this study to minimize observer bias and facilitate participant randomization. Senior clinician at the HIV clinic will supervise the trial and administration of treatments for HAART patients attending at the MRRH clinic.
To endure blinding, a study nurse will randomize and interview the participants and or draw blood whenever necessary. Study phlebotomist will draw blood and deliver it to the respective laboratory with codes masking the arm in which that patient is randomized. Independent laboratory technicians will run the tests at Epicenter and MUST research Labs.

moringa stenopetala/غثيان

Evaluation of Artemisia Annua and Moringa

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم