Day 1: Patients receive two doses 400 mg of Hydrochloroquine in 12 hours interval and 500 mg of Azithromycin once in 24 hours (with the first dose of hydrochloroquine)
Days 2-5: Patients receive two doses 200 mg of Hydrochloroquine in 12 hours interval 250 mg of Azithromycin once in 24 hours (with the first daily dose of hydrochloroquine)

Day 1: Patients receive two doses 400 mg of Hydrochloroquine in 12 hours interval and placebo once in 24 hours (with the first dose of hydrochloroquine)
Days 2-5: Patients receive two doses 200 mg of Hydrochloroquine in 12 hours interval and placebo once in 24 hours (with the first dose of hydrochloroquine)

• Day 1-5: Patients receive two doses of placebo in 12 hours interval and 1 extra dose of placebo once in 24 hours

COVID-19

Respiratory Failure

orally or into nasogastric tube for 5 days

Azithromycin

Hydroxychloroquine

Placebo

František Duška

Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial

Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care Due to Coronavirus Disease 2019 (COVID-19)- Randomised Controlled Trial

Composite percentage of patients alive and not on end-of-life pathway who are free of mechanical ventilation at day 14.

Composite percentage of patients alive and not on end-of-life pathway who are free of mechanical ventilation at day 14 in the subgroup of patients without the need of mechanical ventilation at baseline.

Proportion of patients who died by day 28

Proportion of patients who died by day 90

Deidentified record-level data will be shared in a public database

Frantisek Duska, MD, PhD

Masaryk Hospital Usti nad Labem

University Hospital Pilsen

The Faculty Hospital Na Bulovce

St. Anne's University Hospital Brno, Czech Republic

University Hospital, Motol

General University Hospital, Prague

University Hospital Olomouc

Prospective, multi-centre, randomised, pragmatic, double blind trial

Visually unrecognisable IP or placebo will be prepared by dedicated unblinded study pharmacist and handed over to care provider immediately before administration

receiving 1 tablet per day of celiprolol (Celiprol®) 200 mg in the morning from the first postoperative day after pneumonectomy or bi lobecomty for 2 weeks.

receiving 1 capsule per day of diltiazem (Monotildiem® LP) 200 mg in the morning from the first postoperative day after pneumonectomy or bi lobectomy for 2 weeks.

Postoperative Cardiac Complication

receiving 1 tablet per day of Celiprolol 200 mg in the morning from the first postoperative day after pneumonectomy or bi lobecomty for 2 weeks.

Celiprolol

receiving 1 tablet per day of Diltiazem 200 mg in the morning from the first postoperative day after pneumonectomy or bi lobecomty for 2 weeks.

Diltiazem

Hospital Abderrahmane Mami

Celiprolol Versus Ditiazem for the Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery

Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery : Celiprolol Versus Diltiazem

MahmoudMARZOUK

Medical Doctor anesthesiology and intensive care

Abderrahmane Mami Hospital

Reestablish of invasive mechanical ventilation

Myasthenia Gravis

Reintubation was defied by the reinstitution of invasive mechanical ventilation following extubation at any time

myasthenia gravis/نقص الأكسجة

Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial

Celiprolol Versus Ditiazem for the Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery

Variables Predicting Reintubation After Thymectomy in Patients With Myasthenia Gravis

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