neuroblastoma/ألبيومين

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Ischemia-modified albumin as a biochemical marker in children with neuroblastoma and soft tissue sarcomas.

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In this study, the levels of ischemia-modified albumin (IMA) in pediatric oncology patients with soft tissue sarcomas (STSs) and neuroblastoma (NB) were analyzed. To date, there have been no studies concerning IMA in these groups of patients. Ninety-nine children with STSs and NB were analyzed from

Human serum albumin enhances sodium currents in NH15-CA2 neuroblastoma x glioma hybrid cells.

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The effect of human albumin on neuronal voltage-dependent Na+ channels was studied in NH15-CA2 neuroblastoma x glioma hybrid cells. At an albumin concentration of 32 g/l, the transient Na+ currents, elicited at 1 Hz and recorded with the whole-cell technique, were increased to 125% the control

Comparative toxicity of amyloid beta-peptide in neuroblastoma cell lines: effects of albumin and physalaemin.

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1. Synthetic amyloid beta-peptide was toxic to NB41A3 neuroblastoma cells in serum-free culture as judged by decreasing cell numbers and release of the cytosolic enzyme, lactic dehydrogenase. 2. Without amyloid beta-peptide, bovine serum albumin increased the number of cells surviving in culture. 3.

Albumin prevents mitochondrial depolarization and apoptosis elicited by endoplasmic reticulum calcium depletion of neuroblastoma cells.

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Serum albumin protects against cell death elicited by various cytotoxic agents; however, conflicting views on the protective mechanism still remain. Hence, we have studied the ability of serum albumin to prevent apoptosis of human neuroblastoma SH-SY 5 Y cells elicited by four compounds known to

Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: Preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line.

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Pyrazolo[3,4-d]pyrimidine derivatives 1-5, active as c-Src inhibitors, have been selected to be formulated as drug-loaded human serum albumin (HSA) nanoparticles, with the aim of improving their solubility and pharmacokinetic properties. The present study includes the optimization of a desolvation

Correlation of immune complexes in disseminated neuroblastoma with serum antibody to bovine serum albumin.

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To evaluate the relationship between tumor burden and circulating immune complexes (IC) in children with neuroblastoma (NBL), we studied sera collected at intervals from patients with disseminated (Stage III or IV) NBL. Sera from 10 of 12 patients contained IC by the Raji cell assay at some time

Synthesis of antigens, cross-reactive with bovine serum albumin, by cultured neuroblastoma cells.

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Antisera to bovine serum albumin (BSA) react with biosynthetic products of the LAN-1 neuroblastoma cell line. This immunological reaction was shown by analysis of immunoprecipitates prepared with anti-BSA and products of this cell line intrinsically labeled by the incorporation of 3H- or 35S-labeled

[The effect of the high-molecular components of the blood serum--gamma-globulin and albumin--on the sodium channel activity of neuroblastoma cells].

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Blood serum gamma-globulin and albumin were tested for their effect on the sodium currents of voltage clamped internally perfused serum deprived neuroblastoma cells. Albumin in the concentration corresponding to its content in 5% blood serum (22 microM) produced an increase in sodium channel

Secreted protein acidic and rich in cysteine (SPARC) induces lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids.

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SPARC is a matrix protein that mediates interactions between cells and the microenvironment. In cancer, SPARC may either promote or inhibit tumor growth depending upon the tumor type. In neuroblastoma, SPARC is expressed in the stromal Schwannian cells and functions as a tumor suppressor. Here, we

Bovine serum albumin selectively increases the low-voltage-activated calcium current of NG108-15 neuroblastoma x glioma cells.

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The effect of bovine serum albumin (BSA) on the neuronal Ca2+ current (ICa) has been studied in NG108-15 cells. BSA selectively increased the low-voltage-activated (l-v-a), transient ICa but did not affect the high-voltage-activated (h-v-a) ICa. The increase of l-v-a ICa was partly due to a small

Synthesis of antigens, cross-reactive with bovine serum albumin, by cultured neuroblastoma cells.

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Comparative binding of swertiamarin with human serum albumin and α-1 glycoprotein and its cytotoxicity against neuroblastoma cells.

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Veno-occlusive disease of the liver in children with solid tumors undergoing autologous hematopoietic progenitor cell transplantation: a high incidence in patients with neuroblastoma.

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We retrospectively analyzed the incidence and risk factors for veno-occlusive disease (VOD) in 83 consecutive children with solid tumors, who underwent autologous blood or bone marrow (BM) transplantation at UCSF between 1992 and 2000. Forty-one patients were diagnosed with neuroblastoma and 42 had

Ganglioside-dependent adhesion events of human neuroblastoma cells regulated by the RGDS-dependent fibronectin receptor and proteoglycans.

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Human neuroblastoma cells (Platt and La-N1) adhere and extend neurites on a ganglioside GM1-binding substratum provided by cholera toxin B (CTB). These adhesive responses, similar to those on plasma fibronectin (pFN), require the mediation of one or more cell-surface proteins [G. Mugnai and L. A.

Multifunctional Effect of Human Serum Albumin Reduces Alzheimer's Disease Related Pathologies in the 3xTg Mouse Model.

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Alzheimer's disease (AD), the prevalent dementia in the elderly, involves many related and interdependent pathologies that manifests simultaneously, eventually leading to cognitive impairment and death. No treatment is currently available; however, an agent addressing several key pathologies

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