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niacin/ضمور

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الصفحة 1 من عند 42 النتائج

Effect of niacin on retinal vascular diameter in patients with age-related macular degeneration.

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OBJECTIVE Niacin is a B vitamin well-known for causing vasodilation and flushing. The purpose of this study was to investigate its effect on the retinal vasculature of patients with age-related macular degeneration (AMD). METHODS Twelve patients with AMD were enrolled in a double-blind, randomized,

Effect of niacin on the choroidal circulation of patients with age related macular degeneration.

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OBJECTIVE To investigate the effects of niacin on choroidal blood flow in age related macular degeneration (AMD). METHODS 12 AMD patients with bilateral drusen and visual acuity of 20/40 or better in the study eye received a single oral dose of niacin (six subjects received 500 mg and six received

The biochemical pathways of central nervous system neural degeneration in niacin deficiency.

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Neural degeneration is a very complicated process. In spite of all the advancements in the molecular chemistry, there are many unknown aspects of the phenomena of neurodegeneration which need to be put together. It is a common sequela of the conditions of niacin deficiency. Neural degeneration in

A rare case of alcoholic pellagra encephalopathy with startle myoclonus and marked response to niacin therapy: time for a new dictum?

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We report a case of 56-year-old man, chronic alcoholic, presented to us with progressive weakness in all the four limbs with stiffness and gait disturbance since 1-year associated with cognitive impairment. On examination he had mild confusion, spastic quadriparesis with brisk reflexes, extensor

The effects of phthalate esters on the tryptophan-niacin metabolism.

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Several phthalate esters (PhE), used as a plasticizer for numerous plastic devices, induce liver tumors and testicular atrophy, although the precise nature and mechanism for the action of PhE on these organs have remained unclear. We have previously reported that the administration of a large amount

Cholesterol efflux and the effect of combined treatment with niacin and chromium on aorta of hyperlipidemic rat.

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Endothelial cells may play a potential role in cholesterol efflux from peripheral tissues to liver. Cholesterol efflux from cells is essential for activation of the reverse cholesterol transport pathway and cardiovascular health. One of the cholesterol transporters is steroidogenic acute regulatory

Niaspan, the prolonged release preparation of nicotinic acid (niacin), the broad-spectrum lipid drug.

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Niacin (nicotinic acid) is the broad-spectrum lipid drug, which lowers the concentration of all atherogenic plasma lipids/lipoproteins and at the same time raises the levels of the protective HDL (high-density lipoprotein). Niaspan is a prolonged release (PR) formulation of niacin, which has

Effect of Extended-Release Niacin/Laropiprant Combination on Plasma Adiponectin and Insulin Resistance in Chinese Patients with Dyslipidaemia.

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OBJECTIVE This study examined whether the increase of adiponectin associated with extended-release (ER) niacin/laropiprant combination attenuates the adverse effect of niacin on glucose and insulin resistance in Hong Kong Chinese patients with dyslipidaemia. METHODS Patients (N = 121) were treated

Protective effects of lipoic acid-niacin dimers against blue light-induced oxidative damage to retinal pigment epithelium cells.

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AIM
To evaluate the protective effects of lipoic acid-niacin (N2L) dimers against blue light (BL)-induced oxidative damage to human retinal pigment epithelium (hRPE) cells in vitro.

hRPE cells were divided into a control group (CG), a BL group, an N2L plus

Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide.

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6-Aminonicotinamide (6-AN) is a niacin antagonist, which leads to degeneration of gray matter astrocytes. Metallothionein 1+2 (MT-1+2) are neuroprotective factors in the central nervous system (CNS), and to determine the roles for MT after 6-AN, we have examined transgenic mice overexpressing MT-1

Effects of niacin deficiency on pyridine nucleotide levels and enzyme activities in various organs of young growing quail.

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Three experiments were carried out to determine the effects of feeding a niacin-free diet (NFD) to immature quail. The first two experiments demonstrated that the results were influenced by the age of the birds. Birds placed on test at 4 weeks of age (57 g) had reduced growth rates but did not

The effect of pioglitazone and extended-release niacin on HDL-cholesterol in diabetes patients in a real-world setting.

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OBJECTIVE This retrospective study was designed to assess the effects of the combination of pioglitazone and extended-release niacin on the lipid panel, particularly HDL-cholesterol, when used in patients with type 2 diabetes in an endocrinology specialty practice. METHODS The electronic medical

Niacin-respondent subset of schizophrenia – a therapeutic review.

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It is well known that niacin deficiency manifests with several psychiatric manifestations. Also historically evidence has accumulated that niacin augmentation can be used for treatment of schizophrenia. However, the etiopathological associations between niacin deficiency and schizophrenia as well as

Niacin in cardiovascular prevention: mechanisms, efficacy, and safety.

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OBJECTIVE This review describes niacin's mechanism of action, efficacy in cardiovascular prevention, and safety. RESULTS A G-protein-coupled receptor [GPR109A/HM74A, mouse PUMA-G (protein upregulated in macrophages by interferon-gamma)] was found to mediate the antilipolytic effect of niacin via

Enteric gliopathy in niacin-deficiency induced by CNS glio-toxin.

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6-Aminonicotinamide (6-AN), an antagonist of niacin and a potent CNS glio-toxin, selectively caused degeneration of glial cells in the central nervous system (CNS) of rodents. Suckling mice treated with 6-AN developed diarrhea clinically and displayed vacuolated degenerating glial cells in the
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