Osteopenia

Osteoporosis

Participants in the interventions groups (i.e. colostrum supplementation) will take a colostrum mixture for 5 months (5 times per week; a total of 250ml per day in liquid form). Participants in the placebo groups (i.e. controls) will be taking a placebo mixture (a total of 250ml per day in liquid form per dose) for the same period of time.

Colostrum supplementation for bone loss

FAME Lab, Department of Exercise Science, University of Thessaly

The Effects of Bovine Colostrum in Bone Metabolism in Humans

The alkaline phosphatase (μg/L) will be analyzed via human serum samples using an appropriate ELISA kit

The osteocalcin (μg/L) will be analyzed via human serum samples using an appropriate ELISA kit

The deoxypyridinoline (mmol/L) will be analyzed via human serum samples using an appropriate ELISA kit

The C-terminal telopeptide (CTX) (pg/mL) will be analyzed via human serum samples using an appropriate ELISA kit

The bone mineral density (g/cm2) will be analyzed via Dual-energy X-ray absorptiometry scan

The bone mineral content (gr) will be analyzed via Dual-energy X-ray absorptiometry scan

Petros Dinas

Senior Researcher in human physiology

European Commission

Arthroplasty, Replacement, Hip

Intended to prevent periprosthetic loss of bone mineral density

Denosumab

Keck Medicine of USC

Longjohn Amgen Study - Effect of Denosumab...

Effect of Denosumab in Reversing Periprosthetic Bone Loss Following Hip Replacement

The primary outcome variable will be the difference in loss of bone mineral density between the experimental group taking denosumab and the placebo control group.

Bone turnover differences between the experimental group taking denosumab and the placebo control group.

Donald Longjohn

Assistant Professor of Clinical Orthopaedics

University of Southern California

Orthopaedic Institute for Children

Osteoporosis in Post-menopausal Women

Whole body vibration

GP Office Dr. Baumann

X-pert Med GmbH, MUC

X-pert Med GmbH, Jena

Sportmedizin Stockach

Sophien- und Hufeland- Klinikum GmbH

Safety and Efficacy of Whole-body Vibration as add-on Treatment of Osteoporosis in Post-menopausal Women

Multicentered, Randomized Study of Safety and Efficacy of Whole-body Vibration as add-on to Standard Pharmacological Treatment of Osteoporosis in Post-menopausal Women

1. Changes in markers of bone formation (N-terminal propeptide of type-1 procollagen - P1NP) and bone resorption (cross links of N-terminal telopeptide of type 1 collagen - N-Tx) from baseline to week 6

osteonecrosis/phosphatase

The Effects of Bovine Colostrum in Bone Metabolism in Humans

Longjohn Amgen Study - Effect of Denosumab...

Safety and Efficacy of Whole-body Vibration as add-on Treatment of Osteoporosis in Post-menopausal Women

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