When assigned to the group "Standard monitoring":
In the area of the forehead of the patient, the adhesive electrode is attached according to manufacturer's instructions before the first dose of sedatives. The sedation monitoring is performed under standard conditions by continuous measurement of oxygen saturation, continuous circulatory monitoring (heart rate and regular non-invasive blood pressure measurements) and half-hourly venous blood gas analysis, on receipt in the left atrium an additional arterial blood gas analysis. The examiner (doctor or physicians involved in the study) are blinded to the transcutaneous CO2 measurement. An adjustment of the sedation management therefore takes place on the basis of the monitoring measures mentioned above. Transcutaneous CO2 monitoring is recorded in the background (Excel table of all registered values) and also monitored by the sedation assisting nurse and integrated into the standard sedation protocol.

When assigned to the group "Standard monitoring + transcutaneous CO2 monitoring":
In the area of the forehead of the patient, the adhesive electrode is attached according to manufacturer's instructions before the first dose of sedatives. The sedation monitoring is performed under standard conditions by continuous measurement of oxygen saturation, continuous circulatory monitoring (heart rate and regular non-invasive blood pressure measurements) and half-hourly venous blood gas analysis, on receipt in the left atrium an additional arterial blood gas analysis. In this group, the values of transcutaneous, continuous CO2 monitoring, including an alarm sound, are accessible to the treating physicians. Moreover, sedation management is adjusted on the basis of transcutaneous CO2 measurement. The above-mentioned measurements of the standard monitoring are carried out as described, in addition there is the the transcutaneous CO2 monitoring.

Conscious Sedation During Procedure

Ablation of Arrhythmias

The transcutaneous CO2 Monitoring measures the CO2 partial pressure of the skin and in condition of good circulation these values approximate the arterial/venous CO2 partial pressure. The sensor is placed on the forehead. The physician adapts the sedation Management according to the transcutaneous CO2 monitoring.

Standard monitoring + transcutaneous CO2 monitoring

The transcutaneous CO2-sensor is also positioned on the patients' forehead, but the transcutaneous CO2-monitoring is not available for the physician to adapt the sedative management.

Standard monitoring

Ulm University Medical Center, Internal Medicine II

Transcutaneous Carbon-dioxide Monitoring in Electrophysiological Procedures in Deep Sedation

Prospective, Randomised Evaluation of Transcutaneous Carbon-dioxide Monitoring in Complex Electrophysiological Procedures in Deep Sedation

pCO2 change of > 30% of the initial value (measured in mmHg)

pCO2 > 70 mmHg in the venous blood gas analysis

time until the patients is awakened (measured in minutes)

postoperative nausea and vomiting (PONV)/Shivering

Tillman Dahme, MD

Head of electrophysiology department

University of Ulm

receiving 1 tablet per day of celiprolol (Celiprol®) 200 mg in the morning from the first postoperative day after pneumonectomy or bi lobecomty for 2 weeks.

receiving 1 capsule per day of diltiazem (Monotildiem® LP) 200 mg in the morning from the first postoperative day after pneumonectomy or bi lobectomy for 2 weeks.

Postoperative Cardiac Complication

receiving 1 tablet per day of Celiprolol 200 mg in the morning from the first postoperative day after pneumonectomy or bi lobecomty for 2 weeks.

Celiprolol

receiving 1 tablet per day of Diltiazem 200 mg in the morning from the first postoperative day after pneumonectomy or bi lobecomty for 2 weeks.

Diltiazem

Hospital Abderrahmane Mami

Celiprolol Versus Ditiazem for the Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery

Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery : Celiprolol Versus Diltiazem

MahmoudMARZOUK

Medical Doctor anesthesiology and intensive care

Abderrahmane Mami Hospital

Patients undergo radiotherapy QD 5 days a week for 30 fractions. Patients also receive paclitaxel IV over 1 hour and carboplatin IV over 30 minutes once weekly for 6 weeks. Patients undergo FDG-PET/CT imaging between fractions 18 and 19.

Patients undergo an individualized dose of image-guided radiotherapy QD 5 days a week for 30 fractions and undergo 18 F FDG-PET/CT between fractions 18 and 19. Based on the scan results, patients undergo individualized adaptive radiotherapy for the final 9 fractions. Patients also receive paclitaxel and carboplatin as in Arm I.

Stage III Lung Non-Small Cell Cancer AJCC v7

Stage IIIA Lung Non-Small Cell Cancer AJCC v7

Stage IIIB Lung Non-Small Cell Cancer AJCC v7

Undergo FMISO PET/CT (Correlative studies)

18F-Fluoromisonidazole

Carboplatin

Computed Tomography

External Beam Radiation Therapy

Fludeoxyglucose F-18

Undergo individualized adaptive radiotherapy

Image-Guided Adaptive Radiation Therapy

Laboratory Biomarker Analysis

Paclitaxel

Positron Emission Tomography

Stanford Cancer Institute Palo Alto

Augusta University Medical Center

Rush University Medical Center

Indiana University/Melvin and Bren Simon Cancer Center

The James Graham Brown Cancer Center at University of Louisville

University of Michigan Comprehensive Cancer Center

University of Mississippi Medical Center

Saint Luke's Hospital of Kansas City

Washington University School of Medicine

Memorial Sloan Kettering Basking Ridge

Memorial Sloan Kettering Commack

Memorial Sloan Kettering Westchester

Memorial Sloan Kettering Cancer Center

Memorial Sloan Kettering Sleepy Hollow

Memorial Sloan Kettering Nassau

Case Western Reserve University

Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland Clinic Foundation

Cleveland Clinic Cancer Center Independence

Hillcrest Hospital Cancer Center

Cleveland Clinic Cancer Center Strongsville

Cleveland Clinic Wooster Family Health and Surgery Center

University of Oklahoma Health Sciences Center

Fox Chase Cancer Center

Temple University Hospital

Reading Hospital

Medical University of South Carolina

University of Wisconsin Hospital and Clinics

Medical College of Wisconsin

McGill University Department of Oncology

Saskatoon Cancer Centre

Study of Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy in Patients With Stage III Non-small Cell Lung Cancer

Randomized Phase II Trial of Individualized Adaptive Radiotherapy Using During-Treatment FDG-PET/CT and Modern Technology in Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

pericardial effusion/نقص الأكسجة

Transcutaneous Carbon-dioxide Monitoring in Electrophysiological Procedures in Deep Sedation

Celiprolol Versus Ditiazem for the Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery

Study of Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy in Patients With Stage III Non-small Cell Lung Cancer

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم