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phosphatase/سمنة

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الصفحة 1 من عند 37 النتائج

Protein kinase and phosphatase inhibitors

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
INCORPORATION OF SEQUENCE LISTING The contents of the text file named "28856-502C02US_ST25.txt", which was created on Sep. 22, 2010 and is 3 KB in size, are hereby incorporated by reference in their entirety. BACKGROUND OF THE INVENTION Protein kinases are a large class of enzymes which catalyze the

Protein kinase and phosphatase inhibitors and methods for designing them

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
BACKGROUND OF THE INVENTION Protein kinases are a large class of enzymes which catalyze the transfer of the .gamma.-phosphate from ATP to the hydroxyl group on the side chain of Ser/Thr or Tyr in proteins and peptides and are intimately involved in the control of various important cell functions,

Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
SEQUENCE LISTING The sequence listing submitted via EFS, in compliance with 37 CFR .sctn.1.52(e)(5), is incorporated herein by reference. The sequence listing text file submitted via EFS contains the file "SequenceListing6USCNT3," created on Feb. 17, 2010, which is 341,760 bytes in size. FIELD OF

Pharmaceutical and food compositions for preventing or treating diabetes or obesity

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
CROSS-REFERENCE TO RELATED APPLICATIONS This application is a U.S. national phase under the provisions of 35 U.S.C. .sctn.371 of International Patent Application No. PCT/KR2011/004836 filed Jul. 1, 2011 and published on Apr. 12, 2012 as International Patent Application Publication No. WO2012/046945,

Pharmaceutical and food compositions for preventing or treating diabetes or obesity

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
TECHNICAL FIELD The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a

Pharmaceutical and food compositions for preventing or treating diabetes or obesity

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
TECHNICAL FIELD The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a

Modulators of protein tyrosine phosphatases (PTPases)

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION The present invention relates to novel thienopyridines, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors

Modulators of Protein Tyrosine Phosphatases (PTPases)

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

Protein tyrosine phosphatase inhibitor, preparation method and uses thereof

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
CROSS-REFERENCE TO RELATED APPLICATIONS This application is a U.S. National Stage Application of International Application No. PCT/CN2013/075235 filed on May 7, 2013, and published in Chinese as WO 2013/174207 A1 on Nov. 28, 2013. This application claims priority to Chinese Application No.

Protein tyrosine phosphatase inhibitor, preparation method and uses thereof

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION The present invention relates to a protein tyrosine phosphatase inhibitor, to method for preparing the same, and to use thereof in the manufacture of a pharmaceutical composition for the treatment and prevention of diabetes, obesity and cancers. BACKGROUND OF THE

Protein tyrosine phosphatase 1B inhibitor, preparation methods and uses thereof

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION The present invention relates to a class of protein tyrosine phosphatase 1B (PTP1B) inhibitors, and in particular, to a class of novel organic compounds with small molecules which can be used as PTP1B inhibitors. The present invention also relates to a process for producing

Modulators of protein tyrosine phosphatases (PTPases)

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

Modulators of protein tyrosine phosphatases (PTPASES)

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

Protein tyrosine phosphatase inhibitors and methods of use thereof

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION This invention relates to the field of protein tyrosine phosphatase inhibition. BACKGROUND OF THE INVENTION This invention relates to a novel class of phosphonic acid derivatives that are inhibitors of PTP-1B. Reversible protein tyrosine phosphorylation, coordinated by the
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