Patients will be randomized (by block randomization) to Desferal (DFO) treatment.

Patients will be randomized (by block randomization) to isotonic saline treatment.

Diabetes Mellitus, Type 1

It is a blinded randomized cross-over study that investigates the efficacy of DFO (50mg/kg) given i.v before intermittent hypoxia (IH) to improve the cardiorespiratory and angiogenetic response in patients with diabetes.

desferal

It is a blinded randomized cross-over study that investigates the efficacy of isotonic saline given i.v before intermittent hypoxia (IH) to improve the cardiorespiratory and angiogenetic response in patients with diabetes.

Isotonic saline

Karolinska University Hospital

Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes

The absolute amount of endothelial precursor cells in 10 ml of blood

Sergiu Catrina

Senior consultant / associated professor

This is a randomised, double-blind, placebo-controlled, cross-over, single center study of patients with diabetes mellitus type 1 without chronic complications.

Acute Myelogenous Leukemia

Acute Lymphoblastic Leukemia

Chronic Myelogenous Leukemia

High-risk Myelodysplastic Syndrome

Chronic Lymphocytic Leukemia

Advanced Myelofibrosis

TH-302 will be administered as a 30-minute intravenous infusion daily for 5 days every 21 days. Patients who successfully complete a 3-week treatment cycle without evidence of significant treatment-related toxicity or clinically significant progressive disease will continue to receive treatment for up to six cycles.

TH-302

University of Texas M.D. Anderson Cancer Center

Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias

A Phase I Open-Label Study to Assess the Safety, Tolerability and Preliminary Efficacy of TH-302, a Hypoxia-Activated Prodrug, in Patients With Advanced Leukemias

primary myelofibrosis/نقص الأكسجة

Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes

Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم