psoriasis/إعياء

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Psoriasis-associated fatigue: pathogenesis, metrics, and treatment.

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Fatigue, a substantial symptom of psoriasis, is triggered by complex interactions of inflammation in psoriatic disease, both directly via inflammatory cytokines and indirectly via psychological and physiological factors. We provide data and observations that highlight the importance of qualifying

Fatigue in patients with plaque-type psoriasis: lack of an association with plasma cytokines.

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Fatigue is common in patients with psoriasis, and cytokines have been postulated to influence fatigue.This case-control study explored the plasma levels of selected cytokines in patients with psoriasis and compared them with fatigue and other clinical

Fatigue in psoriasis: a phenomenon to be explored.

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Fatigue is a prevalent and substantial phenomenon in many patients with chronic inflammatory diseases, often rated by patients as the most troublesome symptom and aspect of their disease. It frequently interferes with physical and social functions and may lead to social withdrawal, long-standing

Combination therapy of apremilast and biologics in patients with psoriasis showing biologic fatigue.

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Biologics have been shown to constitute a highly effective treatment for patients with psoriasis. However, a significant number of patients treated with biologics will discontinue them due to loss of efficacy over time, a phenomenon known as biologic fatigue or secondary failure. Combination therapy

Effect of Biological Treatment on Fatigue in Psoriasis: A Systematic Review and Meta-Analysis.

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Fatigue is frequent in patients with psoriasis. Though conventional drugs in general have no effect on fatigue, biological agents have demonstrated beneficial effects in several other chronic inflammatory diseases.The objective of the present study was to

Apremilast: A Review in Psoriasis and Psoriatic Arthritis.

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Apremilast (Otezla®) is an orally administered, small molecule inhibitor of phosphodiesterase 4 (PDE4). Apremilast 30 mg twice daily reduced the severity of moderate to severe plaque psoriasis in the phase 3 ESTEEM trials, as well as improving difficult-to-treat nail, scalp and palmoplantar

[Initially undetected de novo psoriasis triggered by nivolumab for metastatic base of the tongue carcinoma].

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Nivolumab is a monoclonal antibody that binds to the PD-1 receptor on T cells and inhibits the interaction with the PD-L1 and PD-L2 ligands on cancer cells. Thus, nivolumab has immunostimulatory properties. The known side effects of this therapy include fatigue, skin rash, dysfunction of the thyroid

[Unilateral neck inflammation in psoriasis].

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Local inflammation and systemic symptoms such as fever, fatigue and loss of appetite suggest the diagnosis of an abscess even if the patient is in a good general physical condition. The site of bacterial penetration should be identified along the corresponding lymphatic vessels. In this case,

Infliximab for the treatment of recalcitrant generalized pustular psoriasis of pregnancy: Report of a challenging case.

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Pustular psoriasis of pregnancy (PPP), also known as impetigo herpetiformis, is a rare gestational dermatosis that may induce life-threatening complications for both the mother and fetus. Treatment of recalcitrant generalized PPP may be challenging as available therapeutic options are limited. We

Patients' perspectives and experience of psoriasis and psoriatic arthritis: a systematic review and thematic synthesis of qualitative studies.

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To describe the range and depth of perspectives and experiences of patients with psoriasis and psoriatic arthritis to inform gaps in patient centred care.MEDLINE, Embase, PsycINFO, CINAHL were searched to April 2018. Thematic synthesis was used to analyse

Etanercept in psoriasis: the evidence of its therapeutic impact.

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BACKGROUND Psoriasis is a chronic inflammatory skin condition for which there is no cure. Treatment options are designed to control the disease symptoms and improve patients' quality of life, and physical and mental function. Established treatments can be effective but are also limited by

Initial experience with routine administration of etanercept in psoriasis.

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BACKGROUND Etanercept and efalizumab recently became available and reimbursed for routine use in severe psoriasis in the Netherlands. The criteria for reimbursement are Psoriasis Area and Severity Index (PASI) > or = 10 (or Skindex-29 > or = 35 if PASI > or = 8 and < 10) and ineffectiveness of

Longterm treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage.

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Fumaric acid preparations are used as longterm and effective treatment of psoriasis. Apart from gastrointestinal, dermatological and hematological side-effects, transient renal damage was observed during treatment with fumaric acid. The case of a 38 year old woman who was treated with fumaric acid

Severe acute toxoplasmosis infection following ustekinumab treatment in a patient with psoriasis vulgaris.

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A 26-year-old man undergoing therapy with 45 mg ustekinumab (Stelara) for chronic psoriasis vulgaris was referred by his general practitioner to an infectious diseases department for fatigue, fever, night sweating, generalised lymphadenomegaly and unexplained weight loss. Physical examination

Effect of sofosbuvir plus daclatasvir for treatment of chronic hepatitis C on patients with psoriasis.

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Until recently, clinicians caring for patients with psoriasis who were infected with hepatitis C virus (HCV) were concerned that treating one condition could exacerbate the other. We evaluated the outcome of treatment with direct-acting antiviral agents (DAAs) on patients with

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