16 old participants (55-65 years) were included in physical inactivity or bed rest with supervised recovery intervent and underwent 14-day of bed rest. Bed rest was followed by 28-day recovery. During the bed rest participants will remain 24-hour horizontal with all daily activities performed lying in a bed. No social isolation will be forced. During the recovery participants will 3-times weekly per 75 minutes perform guided exercises to achieve baseline level.

7 young participants (18-30 years) were included in physical inactivity or bed rest with supervised recovery intervent and underwent 14-day of bed rest. Bed rest was followed by 28-day recovery. During the bed rest participants will remain 24-hour horizontal with all daily activities performed lying in a bed. No social isolation will be forced. During the recovery participants will 3-times weekly per 75 minutes perform guided exercises to achieve baseline level.

Muscular Atrophy

All (older and younger) participants underwent 14 day of horizontal bed rest with all 24 hour daily activities were performed lying in a bed. Maximal one pillow was allowed. 28-day supervised recovery was performed 3 times weekly for 75 minutes/session.

physical inactivity or bed rest with supervised recovery

Orthopaedic Hospital Valdoltra

Effect of 14 Day Bed Rest on Health Outcomes in Young and Older Participants

CB147 - Physical Activity and Nutrition for Quality Ageing

Using MRI continous screening of single leg was performed

Biopsy samples were obtained from vastus lateralis muscles

graded cycling on sitting ergometer until exhaustion

Estimated from single leg isometric maximal voluntary contraction

estimated from bilateral efforts on explosive ergometer (EXER)

Walking through the food placement detection system

collected hourly for 6 hours after standard meal load as a measure of insulin sensitivity index

collected hourly for 3 hours after standard meal load

From Tensiomyographic response in vastus lateralis

The data is shared among partners for various publications

University of Primorska

University of Trieste

University of Udine

University of Padova

Università degli Studi di Ferrara

University of Nottingham

DLR German Aerospace Center

Izola General hospital

National Institute of Public Health, Slovenia

Injection, 500 mg, single use, over 15 to 20 minutes.

In Control arm, patients will receive the standardized surgical treatment without receiving methylprednisolone preoperatively (placebo).

Complications

Patients in Methylprednisolone arm will receive injection methylprednisolone 500 mg I/V over 15 to 20 minutes, single dose, 30 minutes before starting surgery.

Methylprednisolone

Patients in the placebo group will receive standard perioperative care and surgery, without preoperative administration of methylprednisolone.

pulmonary embolism/carbohydrate

Effect of 14 Day Bed Rest on Health Outcomes in Young and Older Participants

Preoperative Glucocorticoid Use in Major Hepatectomy

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