Acute inflammation is defined as a CRP ≥ 10 mg/l. We will include 2 groups of participants:
A group with an inflammatory syndrome and infection; infection being defined as:
Viral infection confirmed by nasopharynx swab for: influenza, RSV, parainfluenza, rhinovirusses, coronavirusses.
Bacterial infection confirmed with positive blood culture, positive articular punction, positive expectorations, pneumonia on chest radiograph, or infection documented by abdominal imagery (CT or echo), a positive urine culture with a confirmed pyelonephritis with a renal echography or a DMSA scintigraphy or specific clinical symptoms for pyelonephritis and positive hemoculture. A positive urine culture alone is not considered as urine infection because of the high prevalence of asymptomatic bacteriuria in geriatric patients.

Acute inflammation is defined as a CRP ≥ 10 mg/l. We will include 2 groups of participants:
=> B) A group with inflammatory syndrome and inflammatory diseases without infection: defined as:
Confirmed pulmonary embolism (PE) by CT or ventilation-perfusion scintigraphy
Microcrystalline arthritis diagnosed by articular punction
Crush syndrome or rhabdomyolyses defined by history of a fall and raised creatine kinase in blood sample.

White Blood Cells Engulfing Red Blood Cells

No intervention, observational study

Usefulness of White Blood Cell Count (WBCC) During Infection in Geriatric Patient

Usefulness of White Blood Cell Count (WBCC) During Infection: a Comparison Between Hospitalized Geriatric and Young Groups.

observation of WBCC is correlated with infection by older patient

data will be maybe described in an article

Nathalie compté

Clinic head of geriatric unit

Universitair Ziekenhuis Brussel

Patients treated with temocillin and sampled as per the protocol

Pharmacokinetics

Antibacterial Agents

Infections, Bacterial

Infection

Drug Monitoring

Temocillin

Drug dosing and blood sampling as per the protocol

temocillin

AZ Delta ziekenhuis

Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients

Plasma Protein Binding and Population Pharmacokinetics and Pharmacodynamics of Total and Unbound Temocillin in Patients With Complicated Urinary Tract Infection or Pyelonephritis, Lower Respiratory Tract Infection, or Abdominal Infection.

Measurement of total plasma temocillin concentrations (measurement by a validated HPLC-MS-MS after suitable extraction; no predefined value set [exploratory])

Measurement of unbound plasma temocillin concentrations (measurement by a validated HPLC-MS-MS after separation from protein-bound temocillin; no predefined value set [exploratory])

Analysis of the antibiotic pharmacokinetic profiles by means of appropriate software to calculate the actual mean and median values of the total and free plasma Cmax of temocillin (in mg/L) in the study population and to determine their value in a simulated population (Monte Carlo simulations; 1000 simulated patients)

Analysis of the antibiotic pharmacokinetic profiles by means of appropriate software to calculate the actual mean and median values of the total and free plasma Cmin of temocillin (in mg/L) in the study population and to determine their values in a simulated population (Monte Carlo simulations; 1000 simulated patients)

Analysis of the antibiotic pharmacokinetic profiles by means of appropriate software to calculate the actual mean and median values of the fraction of the time between two successive drug administrations during which the total and free plasma concentrations of temocillin remain above a critical value (8 mg/L) in the study population, and to determine its value in a simulated population (Monte Carlo simulations; 1000 simulated patients)

Assessment of the impact of patient's weight [in kg]

Assessment of the impact of patient's height [in cm]

Assessment of the impact of patient's age [in years]

Assessment of the impact of total plasma protein [in g/L] [in g/L].

Assessment of the impact of plasma albumin [in g/L].

serum hepatic transaminases [in international units/L, with reference fo the local normal values]

Paul M. Tulkens

Professor

All patients will be simultaneously studied (disregarding the nature of their infection or the dose/schedule of temocillin)

End Stage Renal Disease

No intervention

Herlev Hospital

Peridialysis Project: The Influence of Predialysis Factors on the Initial Course of Dialysis

Planned dialysis
The patient's first dialysis is planned if:
His first hemodialysis uses an AV fistula
His first hemodialysis uses a permanent catheter as the patient's permanent access
His first peritoneal dialysis is >6 days after catheter placement.
The patient's first dialysis is unplanned if:
His first hemodialysis uses a temporary catheter
His first hemodialysis uses a permanent catheter as the patient's temporary access (i.e. a later AV fistula is planned.
His first peritoneal dialysis is <7 days after catheter placement.

pyelonephritis/ألبيومين

Usefulness of White Blood Cell Count (WBCC) During Infection in Geriatric Patient

Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients

Peridialysis Project: The Influence of Predialysis Factors on the Initial Course of Dialysis

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم