Patients will be randomized at a ratio of 2:1, to hyperbaric chamber (100% oxygen at 2 ATA)

Patients will be randomized at a ratio of 2:1, to Sham chamber (21% oxygen at 1 ATA)

T1DM

HBOC group will receive 100% oxygen at 2 ATA for 90 min with 5 min air breaks every 20 min at each session. Intensive management period includes 60 daily sessions, 5 days per week within 12 weeks,

Hyperbaric oxygen chamber (HBOC)

sham Hyperbaric oxygen chamber (HBOC)

Efficacy of Hyperbaric Oxygen Therapy (HBOT) in New-onset Type-1 Diabetes Mellitus

Double Blind, Randomized Controlled Study to Evaluate the Efficacy of Hyperbaric Oxygen Therapy (HBOT) in New-onset Type-1 Diabetes Mellitus

Difference between treatment groups (HBOT/SHBC) in change of β cell function (measured by AUC of stimulated C peptide) from screening to end of study (52 weeks).

Difference between treatment groups (HBOT/SHBC) in change of β cell function (measured by C-max of stimulated C peptide) from screening to end of study (52 weeks).

Difference between groups in achievement of glycemic targets according to ITDD, with a lower ITDD. assessed by: mean and SD of glucose, CV, time spent in range >70%, and time spent at hypoglycemic range < 1% at end of treatment periods, IDD according to weight.

Assaf Harofeh MC

Head Pediatric Endocrinology Unit

Rebamipide tablets 100mg tid for 8 weeks Esomeprazole tablets 20mg od for 8 weeks

Dyspepsia

Rebamipide

Sugar pill manufactured to mimic Esomeprazole

Placebo (for Esomeprazole)

Esomeprazole tablets 20mg o.d. for 8 weeks

Esomeprazole

University Malaya Medical Centre

Rebamipide in Combination With Esomeprazole in the Management of Asian Patients With Functional Dyspepsia

Rebamipide in Combination With Esomeprazole in the Management of Asian Patients With Functional Dyspepsia: a Multi-national, Randomised, Double-blind, Placebo-controlled Study

To assess the efficacy of Rebamipide in combination with Esomeprazole in the improvement of symptoms of Functional Dyspepsia in Asian patients compared to Esomeprazole alone.

i. To assess the efficacy of Rebamipide in combination with Esomeprazole in the improvement of quality of life in Asian patients with Functional Dyspepsia compared to Esomeprazole alone

To assess the cost-effectiveness of Rebamipide in combination with Esomeprazole compared to Esomeprazole alone after 8, 12 weeks of treatment

To assess the safety of Rebamipide in combination with Esomeprazole in adults with functional dyspepsia after 8 weeks of treatment

quinidine/التهاب

Efficacy of Hyperbaric Oxygen Therapy (HBOT) in New-onset Type-1 Diabetes Mellitus

Rebamipide in Combination With Esomeprazole in the Management of Asian Patients With Functional Dyspepsia

Drug Etiology of Aplastic Anemia and Related Dyscrasias

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم