Washed autologous blood (so as to maintain equivalent unit volume and Hct)

Erythrocyte Transfusion

Rejuvenation refers to the process of adding a mix of solutes (Rejuvesol®, Citra Labs, Braintree, MA; consists of sodium pyruvate, inosine, adenine, mono- and dibasic sodium phosphate) to older, stored (i.e., 2-3 DPG-depleted) blood to immediately restore 2,3-DPG and ATP levels in the stored red blood cells15. Rejuvenation was originally developed to prolong the storage life of rare-phenotype RBC units. It is FDA-approved for use in RBC units stored in CPD, CPDA-1, and AS-1. The major contraindication for the use of Rejuvesol® is in RBC units stored for fewer than 6 days due to high baseline 2,3-DPG and ATP levels. Rejuvenated units must be washed prior to administration to remove residual Rejuvesol that is not approved for iv administration in such concentrations.

Transfusion of rejuvenated and washed autolgous RBCs

Autologous RBCs will be washed prior to transfusion to maintain blinding and equalize volume and Hct with the rejuvenated and washed intervention arm

Transfusion of washed autolgous RBCs

Duke University Medical Center

Rejuvenated RBC and VO2 Max in Healthy Subjects

A Pilot Study on the Impact of Rejuvenated Autologous Blood Transfusion on VO2 Max in Healthy Subjects

Change in VO2max from "anemic" VO2max and after transfusion of 2 units of either standard PRBCs or rej-PRBCs "post-Tx" VO2max.

Change in lactate from "anemic" VO2max and after transfusion of 2 units of either standard PRBCs or rej-PRBCs "post-Tx" VO2max

Change in "post-Tx" VO2max at day 18 from baseline

Duke University

Zimmer Biomet

Prospective randomized "healthy volunteer" study

Addition of rejuvesol will be performed by the blood bank and only they will know of group assignment

Patient will receive standard of care. Subject will have an actiwatch to compare activity and sleep habits. Nursing staff will be aware of study presence but will not receive any specific instruction for the patient.

Patient will abide by the comprehensive care plan and sign an agreement stating compliance. Subject will have an actiwatch to compare activity and sleep habits. Nursing staff will be notified of study and support patient's compliance with study procedures.

Sickle Cell Disease

Sickle Cell Crisis

Vaso-Occlusive Crises

Care Plan
Patient Controlled Analgesia (PCA). PCA will be initiated and managed at the discretion of the Pain Management team.
Other Medications. All medications will be given during daytime hours, if possible.
Pain Psychology.
Physical Therapy. Patient is expected to spend time out of bed by Day 2 participating in light activity.
Sleep Hygiene. Patient sleeps between the hours of 10 PM and 5 AM daily. Window blinds open by 8 AM. Patient must be awake and ready to participate in therapy by 9 AM.
Extracurricular. TV, phone, computer, and video games only between hours of 4-9 PM (computer okay outside of hours only for school work).
Other. Patient will eat meals during regular daytime hours (e.g. breakfast consumed before 9 am) and shower daily.

Comprehensive Care Plan

Phoenix Children's Hospital

A Comprehensive Care Plan for Pediatric Patients With Vaso-Occlusive Crises

pain scores assessed daily for each patient using the (Visual Analog Scale) VAS scale.

sickle cell trait/إعياء

Rejuvenated RBC and VO2 Max in Healthy Subjects

A Comprehensive Care Plan for Pediatric Patients With Vaso-Occlusive Crises

Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم