silicosis/نيكوتين

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Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis

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Silica dust mainly attacks alveolar macrophages (AMs). The apoptosis of AMs is correlated with the progress of silicosis. Our previous study showed that autophagic degradation was blocked in AMs from silicosis patients. However, the effects of nicotine on AM autophagy and apoptosis in silicosis are

Silica exposure, silicosis, and lung cancer: a mortality study of South African gold miners.

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The effects of exposure to gold mining dust with a high concentration of free silica and tobacco smoking on mortality from lung cancer was assessed in a sample of 2209 white South African gold miners who started mining exposure during 1936-43, and were selected for a study of respiratory disorders

High prevalence and advanced silicosis in active granite workers: a dose-response analysis including FEV1.

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OBJECTIVE To evaluate silica exposure and respiratory disease in granite workers. METHODS A cross-sectional study of 440 active granite workers. RESULTS Seventy-seven (17.5%) have silicosis, complicated in 15 of them; 18 have an obstructive ventilatory defect and 73 had exceeded 3.5 mg/m-year of

Silicosis, chronic airflow limitation, and chronic bronchitis in South African gold miners.

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In a cross-sectional study of a working population of black South African gold miners, 1,197 men were studied with respiratory and occupational questionnaires, lung function tests, and chest radiographs. The study was designed to examine the effects of silicosis on respiratory symptoms and lung

Electrocardiographic signs of chronic cor pulmonale in 40 376 patients with silicosis.

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The records of all patients who were examined for silicosis at the Fund of Occupational Diseases between 1972 and 1976 are reviewed. In 3627 cases the mechanographical record was incomplete leaving 40 376 patients in the study. Electrocardiographic signs of chronic cor pulmonale (C.C.P.) were

Lung cancer in relation to exposure to silica dust, silicosis and uranium production in South African gold miners.

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BACKGROUND A nested case-control study for lung cancer was performed on a cohort of 2260 South African gold miners in whom an association between exposure to silica dust and risk of lung cancer was previously reported. The objective was to investigate an expanded set of risk factors and also cancer

Tobacco smoke exposure exacerbated crystalline silica-induced lung toxicity in rats

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Smoking may modify the lung response to silica exposure including cancer and silicosis. Nevertheless, the precise role of exposure to tobacco smoke (TS) on the lung response to crystalline silica (CS) exposure and the underlying mechanisms need further clarification. The objectives of the present

Club cell protein 16 as a biomarker for early detection of silicosis

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Background & objectives: Clinically silicosis is diagnosed by chest X-ray showing specific opacities along with history of silica dust exposure. Diagnosis is invariably made at an advanced or end stage when it is irreversible.

Risk of pulmonary tuberculosis relative to silicosis and exposure to silica dust in South African gold miners.

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OBJECTIVE To investigate the following questions. (1) Is silica dust on its own, without the presence of silicosis, associated with an increased risk of pulmonary tuberculosis (PTB) in workers exposed to silica dust? (2) In the absence of silicosis is the excess risk dose related? (3) What is the

Introduction: 'dying for gold': the effects of mineral miningon HIV, tuberculosis, silicosis, and occupational diseases in southern Africa.

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Mineral mining is among the world's most hazardous occupations. It is especially dangerous in southern Africa, where mining activity is a leading cause of HIV and tuberculosis epidemics. Inside mines, silica dust exposure causes long-term pulmonary damage. Living conditions are often substandard;

Identifying patients at high risk of tuberculosis recurrence.

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Several studies have been done in relation to recurrence of tuberculosis (TB) following completion of treatment. However, recurrence of TB is still a major problem from a public health perspective in high-burden countries, where no special attention is being given to this issue. Disease recurrence

Correlation between autopsy findings for chronic obstructive airways disease and in-life disability in South African gold miners.

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OBJECTIVE In South Africa chronic obstructive airway disease (COAD), which could be due to working in a dusty atmosphere in scheduled mines or works, is a compensatable disease. Miners are compensated for in-life respiratory disability and for findings at autopsy of COAD, which includes emphysema,

Determinants of chronic bronchitis and lung dysfunction in Western Australian gold miners.

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The relation of chronic bronchitis and respiratory dysfunction to age, tobacco smoking, and occupational exposure to surface and underground mining operations were examined in a cross sectional survey of 1363 men employed in the Kalgoorlie mining industry in 1985. Overall, the prevalence of chronic

Changes in lung function of granite crushers exposed to moderately high silica concentrations: a 12 year follow up.

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45 granite crushers and 45 age and smoking matched referents underwent pulmonary function tests in 1976 and 1988. On average, the granite crushers at follow up had worked for 22 years, were 52 (range 36-78) years old, and had inhaled a cumulated amount of 7 mg of silica in the respirable dust

[Characteristics of lung cancer in patients exposed to silica at work. A comparison of exposed and non-exposed individuals].

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BACKGROUND In 1977 silica was listed as a group 1 carcinogen (demonstrated in humans) by the International Agency for Research on Cancer. However, conflicting results from various studies have kept debate alive as to its carcinogenic capacity. The interest of this debate lies in the large number of

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