Amide and urea derivatives of the formula Iin which R.sup.1, n, Y, q, Z, r and R.sup.2 have the meanings indicated in Claim 1, are potent 5-HT.sub.1B/1D antagonists and exhibit 5-HT reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depressions, schizophrenia, compulsive ideas, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive behaviour (OCD), and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.

Merck Patentgesellschaft

Amide and urea derivatives as 5-HT reuptake inhibitors and as 5-HT1B/1D ligands

Piperazine derivatives of the formula I ##STR1##in whichR.sup.1, m, k and R.sup.2 have the meanings indicated in claim 1, are potent 5-HT.sub.1A agonists and exhibit 5-HT-reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depression, schizophrenia, obsessions, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive disorder, and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.

Merck Patent Gesellschaft mit beschraenkter Haftung

Piperazine derivatives

Pyridone-fused azabicyclic compounds of the formula ##STR1##and their pharmaceutically acceptable salts and prodrugs, wherein R.sup.1, R.sup.2 and R.sup.3 are defined below, intermediates and methods for their preparation. Compositions and methods for using compounds of the formula I in the treatment of neurological and mental disorders related to a decrease in cholinergic function such as nicotine addiction, Huntington's Chorea, tardive dyskinesia, hyperkinesia, mania, dyslexia, schizophrenia, analgesia, attention deficit disorder (ADD), multi-infarct demetia, age related cognitive decline, epilepsy, neurological and mental disorders related to a decrease in cholinergic function, senile dementia of the Alzheimer's type, Parkinson's disease, attention deficit hyperactivity disorder (ADHD), anxiety, obesity, Tourette's Syndrome and ulcerative colitis.

tardive dyskinesia/احتشاء

Amide and urea derivatives as 5-HT reuptake inhibitors and as 5-HT1B/1D ligands

Piperazine derivatives

Pyridone-fused azabicyclic- or cytisine derivatives, their preparation and their use in addiction therapy

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم