trillium cuneatum/سرطان

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Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer.

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Trillium tschonoskii Maxim (TTM), a traditional Chinese medicine, has been demonstrated to have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from TTM, was reported by us to significantly suppress the proliferation of non-small cell lung cancer (NSCLC)

Paris saponin VII extracted from trillium tschonoskii suppresses proliferation and induces apoptosis of human colorectal cancer cells.

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Saponins of many herbs could inhibit the growth of colorectal cancer cells. In the study, we investigated the effects of Paris saponin Ⅶ (PSⅦ), and elucidated its mechanism in colorectal carcinoma cells and a xenograft mouse model.HT-29 and HCT-116 cells

Cytotoxicity of a plant steroidal saponin on human lung cancer cells.

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Trillium tschonoskii Maxim has been used to treat several diseases, including cancers, in folk medicine. The primary objective of the present study was to test whether TTB2, a steroidal saponin isolated from n-BuOH extracts, might exert effects on cell survival, morphology, cell cycle, reactive

Trillium tschonoskii steroidal saponins suppress the growth of colorectal Cancer cells in vitro and in vivo.

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BACKGROUND Saponins of many herbs are known to possess anti-cancer effect. OBJECTIVE The present study aimed to investigate the growth inhibitory effect of Trillium tschonoskii steroidal saponins in a mouse model of colitis-associated colorectal cancer and a human colorectal cancer cell line HT-29,

Paris saponin VII inhibits metastasis by modulating matrix metalloproteinases in colorectal cancer cells.

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Metastasis is the main cause of mortality of patients with cancer-related disease. Targeting the process of metastasis has been proposed as a potential strategy in cancer treatment. Trillium tschonoskii Maxim., a traditional Chinese medicine, is used for the treatment of numerous diseases, including

The rhizome of Trillium tschonoskii Maxim. extract induces apoptosis in human lung cancer cells.

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Trillium tschonoskii Maxim. has been used to treat several diseases including cancers in folk medicine. However, the mechanisms responsible for T. tschonoskii extract-induced apoptosis are not clear. This study was mainly undertaken to identify the major biochemical changes in a lung cancer cell

Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway.

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Dysregulation of the Ras signaling pathway plays a key role in the progression of colorectal cancer. When bound to GTP, Ras is activated and stimulates several downstream effectors' pathways, including the Raf/MEK/ERK kinase cascade, the PI3-kinase/AKT/mTor pathway, and the Ral GTPase pathway.

Paris Saponin VII Inhibits the Migration and Invasion in Human A549 Lung Cancer Cells.

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Metastasis is the main cause of death in lung cancer. Targeting the process of metastasis is a strategy to lung cancer treatment. Trillium tschonoskii Maxim., a traditional Chinese medicine, has been used for treatment of many diseases, including cancer. This study aims to determine the

Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer.

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Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. Our previous studies have proven that Trillium tschonoskii Maxim. (TTM), a traditional Chinese medicine, possesses potent anti-tumor effect. However, the detailed components and molecular mechanism of TTM in

A comparative assessment of attendance and nonattendance at Camp Trillium by children with cancer and their families; including their utilization of health and social services.

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BACKGROUND Camping programs for children with chronic diseases are designed for specific needs, but rigorous evaluation of their impact is largely lacking. The biggest camp for children with cancer and their families provided an opportunity to conduct such an investigation. METHODS The study sample

Paris saponin VII from trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7/ADR cells via P-glycoprotein inhibition and apoptosis augmentation.

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BACKGROUND Saponins of several herbs are known to induce apoptosis in some cancer cells and are proposed to be promising modulators of drug resistance. In the present study, we extracted Paris saponin VII (PS VII), a kind of saponin, from Trillium tschonoskii Maxim. and observed its effect on

Chemical constituents of Trillium tschonoskii Maxim.

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A new fatty acid-spirostan steroid glycoside ester, a new cholestane glycoside and a new stilbene trimer, along with three known steroidal saponins, were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium tschonoskii Maxim. The structure of isolated compounds was

Spirostanol and sesquiterpenoid glycosides from the rhizomes of Trillium tschonoskii.

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Three new spirostanol glycosides, trilliumosides K-M (1-3), one new sesquiterpenoid glycoside, tritschsesuquiside A (4), along with three known analogues (5-7) were obtained from the rhizomes of Trillium tschonoskii. The structures of new glycosides were elucidated by spectroscopic analyses (HRMS

Ecological observations and altered indigenous harvesting practices of Trillium govanianum (Melanthiaceae) in Indian Himalayas.

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UNASSIGNED Trillium govanianum Wall. ex D. Don (Melanthiaceae) is valued as a traditional medicinal herb in the Himalayan region. Applications include treatment of cancer, hypertension, neurasthenia, giddiness, arthritis, dysentery, inflammation, sepsis and reproductive disorders. Its range is

Novel steroidal saponin isolated from Trillium tschonoskii maxim. exhibits anti-oxidative effect via autophagy induction in cellular and Caenorhabditis elegans models.

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Emerging evidences indicate the important roles of autophagy in anti-oxidative stress, which is closely associated with cancer, aging and neurodegeneration.In the current study, we aimed to identify autophagy inducers with potent anti-oxidative effect from

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