will receive topical co enzyme q10 in the form of mucoadhesive tablets 3 times daily for 3months.

will receive topical corticosteroid (kenacort A Orabase: triamcinolone acetonide 0.1%5gram adhesive paste - dermapharm), 4 times daily for 3months.

Oral Lichen Planus

Co-Enzyme Q10 mucoadhesive tablets

Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial

11 El-Saraya St. - Manial - Cairo

Mostafa Abdelsamie Bakry Nafie

demonstrator

Cairo University

two parallel group one take Q10 mucoadhesive tablets and other take topical corticosteroid for 3 months follow up measuring pain ,clinical size of lesion and salivary level of Malondialdehyde as oxidative biomarker

Double-blinded trial, outcome assessors and statistician

1) The 'intervention' group: 3-month multimodal approach associating exercise rehabilitation, ONS, n-3 PUFAs and androgen substitution:
Physical rehabilitation including endurance and resistance exercises two to three times a week.
Oral nutritional supplements: Fortimel max® (Nutricia®) (300 ml, 720 kcal, 29 g de proteins), once per day.
n-3 polyunsaturated fatty acids : DHA phospholipids (GPL-DHA®), 240 mg/day.
Testosterone: Testopatch® 2.4 mg in men and 1.2 mg in women; 2 patches renewed every two days.

2) The 'control' group: no multimodal approach but the treatment currently recommended: heart rehabilitation and dietary counseling during 3 months.

Chronic Heart Failure

Physical rehabilitation (exercise).

CHU Clermont-Ferrand

Multimodal Approach of Undernutrition in Chronic Heart Failure

Multimodal Approach of Undernutrition in Chronic Heart Failure : a Controlled, Randomized Trial

University Hospital, Clermont-Ferrand

Durtol clinical center

Centre Hospitalier Universitaire de Saint Etienne

University Hospital, Grenoble

University Hospital, Geneva

Colorectal Cancer

Metastasis

simvastatin

Samsung Medical Center

Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC

Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic Colorectal Cancer

ubiquinone

سرطان

neoplasms

ubiquinone/سرطان

Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial

Multimodal Approach of Undernutrition in Chronic Heart Failure

Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC

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