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The influence of di-acetylation of the hydroxyl groups on the anti-tumor-proliferation activity of lutein and zeaxanthin.

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Lutein and zeaxanthin have various activities such as anti-age-related macular degeneration, anticataract, anticancer and cardiovascular diseases risk lowering, etc.; however, few studies have been reported on the role of free hydroxyl groups in the antitumor effects of lutein and zeaxanthin. The

Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk.

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It is unclear whether dietary lutein/zeaxanthin intake in colorectal cancer is associated with microRNA processing involved in DICER1 cleavage for messenger RNA translation. We investigated whether dietary lutein/zeaxanthin intake affects colorectal cancer risk in patients with a DICER1 rs3742330

Reversal of multidrug resistance of cancer cells in vitro: modification of drug resistance by selected carotenoids.

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The development of multidrug resistance (MDR) causes difficulties in the chemotherapy of of human cancer. Investigation of the possibility of reversal of MDR has been greatly aided by the use of cell lines with acquired resitance to anticancer agents in vitro or transfected with the mdrl gene. The

Liarozole amplifies retinoid-induced apoptosis in human prostate cancer cells.

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Beta-carotene, canthaxanthin and retinoic acid (RA) inhibited growth of human DU145 prostate cancer cells by 45, 56 and 18%, respectively. Lycopene was also found to inhibit cell growth. Other carotenoids including xanthophyll (lutein), cryptoxanthin and zeaxanthin were less effective. Liarozole (a

The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats.

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Zeaxanthin (ZA), an important compound found in Lycium barbarum, shows various pharmacodynamic effects. In our present study, a high-fat, high-sucrose diet and streptozotocin (STZ)-induced diabetic rat model was used to investigate the antidiabetic activities of ZA. After a 4-week administration of

Serum antioxidants and subsequent mortality rates of all causes or cancer among rural Japanese inhabitants.

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The purpose of this study was to investigate whether a relationship exists between mortality rates and serum antioxidant levels among Japanese inhabitants. The follow-up subjects, who participated in comprehensive health examinations, consisted of 2444 inhabitants (949 males and 1495 females) of a

Preoperative levels of plasma micronutrients are related to endometrial cancer risk.

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OBJECTIVE To examine the relation between the plasma concentration of antioxidant micronutrients and endometrial cancer risk in Korean women. METHODS Hospital-based case-control study. METHODS Seven tertiary medical institutes in Korea. METHODS Incidence of 28 endometrial cancer cases were

Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia: a case-control study.

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BACKGROUND Although there have been some epidemiological studies on the effects of diet and nutritional status on cervical carcinogenesis, evidence for a protective effect of antioxidant micronutrients against cervical neoplasia is insufficient. The relationship between serum antioxidant

Dietary carotenoids, vegetables, and lung cancer risk in women: the Missouri women's health study (United States).

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OBJECTIVE To examine the effect of specific dietary carotenoids and their primary plant food sources on lung cancer risk in a population-based case-control study of women. METHODS Data were available for 587 incident primary lung cancer cases and 624 controls frequency matched to cases based on age.

Smoking attenuates the negative association between carotenoids consumption and colorectal cancer risk.

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OBJECTIVE Consumption of vegetables and fruits, physical activity, obesity and caloric intake are all strongly related to the risk of colorectal cancer (CRC). The association between dietary intake of carotenoids from vegetables/fruits and risk of CRC in the context of cigarette smoking was studied

Effects of supplemental beta-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.

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We determined whether serum carotenoid or retinol concentrations were altered by beta-carotene supplementation in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and whether such effects were modified by alcohol consumption or cigarette use. Participants in this substudy were 491

Serum carotenoids and risk of cervical intraepithelial neoplasia in Southwestern American Indian women.

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The objective of this research was to evaluate the association between serum carotenoids and cervical intraepithelial neoplasia (CIN) among Southwestern American Indian women. Cases were American Indian women with biopsy-proven CIN II/III cervical lesions (n = 81) diagnosed between November 1994 and

Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer.

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OBJECTIVE We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. METHODS Hospital-based case-control study. METHODS Six tertiary medical institutes in Korea. METHODS Forty-five epithelial ovarian cancers and 135 age-matched

Dietary carotenoids and risk of colon cancer: case-control study.

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Some epidemiological studies suggest that consumption of fruits and vegetables with a high carotenoid content may protect against colon cancer (CC). The evidence, however, is not completely consistent. Given the inconsistencies in findings in previous studies and continued interest in identifying

Micronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control study.

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OBJECTIVE To investigate the relation between various micronutrients and laryngeal cancer risk. METHODS A case-control study was conducted in Italy and Switzerland between 1992 and 2000. Cases were 527 patients with incident cancer of larynx, admitted to the major teaching and general hospitals of

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