Injection of vitamin A acid, vitamin E, and vitamin C for treatment of tissue necrosis.

Experimental studies concerning All-Trans Retinoic acid 0.1% with the antioxidant action of the Vitamin E (tocopherol acetate 0.20%) and Vitamin C (coated ascorbic acid 0.20%) efficacy in both the vascular neoformation induction and cellular membrane stabilization have been conducted by us to improve skin necrosis regression after routine plastic surgeries. Patients after rhytidectomy, breast reduction, and abdominoplasty with localized skin flap necrosis, were submitted to daily intradermic injections for a period of 15 days and had their skin healed by the effects of these vitamins.