[Interleukin-1 formation during inhibition of proteolytic enzyme activity].

Contrycal and phosphomethylsulfonyl fluoride prevented a decrease in activity of interleukin-1 (IL) in 3-days-old culture of mononuclear cells from human peripheral blood stimulated with lipopolysaccharide. These protease inhibitors did not affect per se the IL formation as distinct from soy bean trypsin inhibitor which developed immunostimulating and pyrogenic activities of IL in the cell culture. Use of contrycal enabled to increase content of IL in human and rabbit whole blood culture stimulated by lipopolysaccharide as well as to reinforce the rate of rabbit fever caused by exogenous pyrogen.