Hypertension (>140 mmHg systolic or >90 mmHg diastolic) developing after 20 weeks gestation and the coexistence of one or more of the following new onset conditions:
Proteinuria (>300 mg/day)
Other maternal organ dysfunction
renal insufficiency (creatinine >90 μmol/L)
liver involvement (elevated transaminases - and/or severe right upper quadrant or epigastric pain)
neurological complications (eclampsia, altered mental status, blindness, stroke, hyperreflexia when accompanied by clonus, severe headaches when accompanied by hyperreflexia, persistent visual scotomata)
hematological complications (thrombocytopenia, disseminated intravascular coagulation, hemolysis)
Uteroplacental dysfunction

New onset of hypertension (>140 mmHg systolic or >90 mmHg diastolic) after 20 weeks gestation, without proteinuria, in a previously normotensive woman.

Babies born alive before 37 weeks of pregnancy are completed.

Moderate IUGR is an estimated fetal weight and / or abdominal circumference < 10th percentile for its gestational age Severe IUGR is an EFW (estimated fetal weight) and/ or AC (abdominal circumference) < 5th percentile for its gestational age

Pregnancy Complications

Endothelial Dysfunction

University Hospital Antwerp

Oxidative Stress and Endothelial Function in Pregnancy Complications

Oxidative Stress and Endothelial Function in Pregnancy Complications: Development of a New Screening Algorithm

Single center prospective longitudinal study: To evaluate the oxidative stress profile in normal pregnancies.
Multicenter matched case-control study: To compare the oxidative stress profile in normal versus complicated pregnancies.

Single center prospective longitudinal study: To evaluate endothelial function in normal pregnancies.
Multicenter matched case-control study: To compare endothelial function in normal versus complicated pregnancies.
To relate endothelial function (using Endopat ®) to nitric oxide/eNOS/superoxide concentration (using EPR and Western Blotting).

Single center prospective longitudinal study: To evaluate arterial stiffness in normal pregnancies.
Multicenter matched case-control study: To compare arterial stiffness in normal versus complicated pregnancies.
To relate Arterial stiffness (using Sphygmocor ®) to nitric oxide/eNOS/superoxide concentration (using EPR and Western Blotting).

Pregnancy outcome will be determined using the diagnostic criteria described in 'groups and interventions'.
Single center prospective longitudinal study and multicenter matched case-control study.
To relate oxidative stress profile to pregnancy outcome.

Single center prospective longitudinal study and multicenter matched case-control study.

Prof Yves Jacquemyn

Professor

Universiteit Antwerpen

University Hospital, Antwerp

Ziekenhuis Oost-Limburg

Maastricht University Medical Center

Erasmus Medical Center

Cutaneous Leishmaniasis

daily nitric oxide patch application during 20 days

controlled nitric oxide releasing patch

meglumine antimoniate

Fundación Cardiovascular de Colombia

Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

Double Blind, Randomized Controlled Trial, to Evaluate the Effectiveness of a Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

ascorbic acid/necrosis

Oxidative Stress and Endothelial Function in Pregnancy Complications

Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

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