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Старонка 1 ад 57 вынікі
Treatment of emesis with morpholine tachykinin receptor antagonists
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
SUMMARY OF THE INVENTION
This invention is concerned with novel compounds represented by structural formula I: ##STR2## wherein R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.11, R.sup.12, R.sup.13, A, B, p, Y and Z are hereinafter defined.
The invention is also concerned with pharmaceutical
Benzoimidazole derivatives and pharmaceutical composition comprising the same
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
TECHNICAL FIELD
The present invention relates, in general, to novel benzoimidazole derivatives and, more particularly, to novel benzoimidazole derivatives functioning as antagonists to a vanilloid receptor (capsaicin receptor; Transient Receptor Potential Channel, Vanilloid subfamily member 1;
Opioid compounds and methods for using same
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates generally to diarylmethyl piperazine compounds having utility in medical therapy especially as receptor-binding species, e.g., as conjugates in agonist/antagonist pairs for verifying/assaying receptor and neurotransmitter
Opioid compounds
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates generally to diarylmethyl piperazine compounds having utility in medical therapy especially as receptor-binding species, e.g., as conjugates in agonist/antagonist pairs for verifying/assaying receptor and neurotransmitter
Opioid compounds and methods for making therefor
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates generally to diarylmethyl piperazine compounds having utility in medical therapy especially as receptor-binding species, e.g., as conjugates in agonist/antagonist pairs for verifying/assaying receptor and neurotransmitter
Piperidine derivatives as substance P antagonists
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
This application is a 371 of PCT/JP96/00796 filed Mar. 27, 1996.
TECHNICAL FIELD
The present invention relates to new piperidine derivatives having an antagonism on Substance P, being a peptide neurotransmitter, and pharmaceutically acceptable acid addition salts thereof. The piperidine derivatives
.DELTA.9 Tetrahydrocannabinol (.DELTA.9 THC) solution metered dose inhaler
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
DESCRIPTION
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention is generally related to the therapeutic use of .DELTA..sup.9 Tetrahydrocannabinol (.DELTA..sup.9 THC). In particular, the invention provides a metered dose inhaler (MDI) for the aerosol administration of .DELTA..sup.9
.DELTA.9 tetrahydrocannabinol (.DELTA.9 THC) solution metered dose inhalers and methods of use
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention is generally related to the therapeutic use of .DELTA..sup.9 Tetrahydrocannabinol (.DELTA..sup.9 THC). In particular, the invention provides a metered dose inhaler (MDI) for the aerosol administration of .DELTA..sup.9 THC to
Polynucleotides that encode the calcitonin gene-related peptide receptor coponent factor (HOUNDC44)
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists
Modulation of substance P by compounds containing calcium sulfate and methods relating thereto
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
TECHNICAL FIELD
The present invention relates generally to a method of modulating substance P by compounds containing calcium sulfate, particularly syngenite, gorgeyite and gypsum, and more specifically, to the synthesis of such compounds as well as their use to treat a variety of conditions
Protein free formula
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention relates to the stimulation of health in infants receiving an amino acid based formula.
BACKGROUND OF THE INVENTION
In a preferred situation, infants are breastfed by the mother. However, often in infants, after an initial period of being breast fed,
Benzyloxyquinuclidines as substance P antagonists
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND OF THE INVENTION
This application is the U.S. national phase of PCT Patent Application PCT/JP94/01092, which was filed in the Japanese Receiving Office on Jul. 5, 1994.
This invention relates to novel and useful benzyloxyquinuclidines of interest to those in the field of medical chemistry
Bi-pyridinyl derivatives as NK-1 antagonists
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
PRIORITY TO RELATED APPLICATIONS
This application claims the benefit of European Application No. 05101324.1, filed Feb. 22, 2005, which is hereby incorporated by reference in its entirety.
BACKGROUND OF THE INVENTION
Substance P is a naturally occurring undecapeptide belonging to the tachykinin
Methods of screening for agonists and antagonists of the interaction between the human KIAA0001 receptor and ligands thereof
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
This invention relates to methods for discovering agonists and antagonists of the interaction between UDP-sugars (e.g.,UDP-glucose, UDP-galactose, UDP-glucuronic acid, and UDP-N-acetyl glucosamine) and their cellular receptor, human KIAA0001 receptor. The invention also
Aroyl-piperidine derivatives and method of treating disorders induced by substance P
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
DETAILED DESCRIPTION OF THE INVENTION
The invention relates to novel N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylamino)-piperidin- es of the formula
##STR00002## wherein Y is .dbd.N-- or .dbd.N(O)--, R is OH when Y is .dbd.N-- and R is H when Y is .dbd.N(O)-- and the ring A is
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