clarithromycin 500 mg twice daily (Biaxin) + fluticasone propionate 88 mcg twice daily (Flovent® HFA 44 mcg two puffs twice daily)

placebo clarithromycin twice daily + fluticasone propionate 88 mcg twice daily (Flovent® HFA 44 mcg two puffs twice daily)

Clarithromycin 500 mg bid (Biaxin) + fluticasone propionate 88 mcg bid (Flovent® HFA 44 mcg two puffs bid)

Clarithromycin + Fluticasone

Fluticasone propionate 88 mcg bid (Flovent® HFA 44 mcg two puffs bid)

Placebo + Fluticasone

Total

Sex: Female, Male

Region of Enrollment

The Juniper asthma control questionnaire (ACQ) consists of six questions answered by the asthma patient with respect to symptoms, rescue medication use, and night-time awakenings due to asthma. A seventh item in the ACQ is the percent predicted FEV1. Each of the seven items is scored from from 0 (best) to 6 (worst), and then the seven items are averaged to yield a number from 0 (best) to 6 (worst). Asthma patients needed to display an ACQ greater than or equal to 1.25 in order to be eligible for randomization. A reduction of 0.5 units or more in the ACQ over the 16 weeks of treatment is considered to be clinically significant.

placebo clarithromycin + fluticasone propionate 88 mcg twice daily (Flovent® HFA 44 mcg two puffs twice daily)

Juniper Asthma Control Questionnaire (ACQ) Results

clarithromycin 500 mg twice daily (Biaxin) + fluticasone propionate 88 mcg twice daily (Flovent® HFA 44 mcg two puffs twice daily)
clarithromycin: clarithromycin 500 mg twice daily (Biaxin)
fluticasone propionate: fluticasone propionate 88 mcg twice daily (Flovent® HFA 44 mcg two puffs twice daily)

placebo clarithromycin twice daily + fluticasone propionate 88 mcg twice daily (Flovent® HFA 44 mcg two puffs twice daily)
fluticasone propionate: fluticasone propionate 88 mcg twice daily (Flovent® HFA 44 mcg two puffs twice daily)
placebo clarithromycin: placebo clarithromycin twice daily

Asthma Rescue Medication Use

daily AM peak expiratory flow (PEF) measured in liters per minute

AM Peak Expiratory Flow (PEF)

Forced expiratory volume in one second (FEV1) from spirometry

Forced Expiratory Volume in One Second (FEV1)

Logarithm-base 2 transformed Methacholine provocative concentration (PC20) based on FEV1

Methacholine Provocative Concentration (PC20)

Exhaled nitric oxide (eNO) measured in parts per billion

Exhaled Nitric Oxide (eNO)

The Asthma Quality of Life Questionnaire (AQLQ) consists of 32 questions, with each question ranging from 1 (worst) to 7 (best). The 32 questions are averaged to yield an overall score, which is reported here. Therefore, a positive change between the 16-week score and the baseline score represents improvement.

Asthma Quality of Life Questionnaire (AQLQ)

Overall Study

Vernon M. Chinchilli, PhD

Asthma

clarithromycin 500 mg twice daily (Biaxin)

clarithromycin

fluticasone propionate 88 mcg twice daily (Flovent® HFA 44 mcg two puffs twice daily)

fluticasone propionate

placebo clarithromycin

Click here for the Asthma Clinical Research Network (ACRN) web site

chlamydia infections/нікацін

Asthma Clinical Research Network (ACRN) Trial - Macrolides in Asthma (MIA)

Infection and Cardiovascular Disease

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