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mycose/злаякасная пухліна
Спасылка захоўваецца ў буферы абмену
13 вынікі
Indole and dihydroindole derivatives
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention is concerned with novel indole and dihydroindole derivatives, their manufacture and their use as medicaments.
BACKGROUND OF THE INVENTION
2,3-oxidosqualene-lanosterol cyclase (EC 5.4.99.) is required for the biosynthesis of cholesterol, ergosterol and
2,3-oxidosqualene-lanosterol cyclase inhibitors
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention is concerned with novel aminocyclohexanol derivatives, their manufacture and their use as 2,3-oxidosqualene-lanosterol cyclase inhibiting medicaments.
BACKGROUND OF THE INVENTION
Causal risk factors that directly promote the development of coronary and
2,3-Oxidosqualene-lanosterol cyclase inhibitors
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention is concerned with novel aminocyclohexanol derivatives, their manufacture and their use as 2,3-oxidosqualene-lanosterol cyclase inhibiting medicaments.
BACKGROUND OF THE INVENTION
Causal risk factors that directly promote the development of coronary and
Heteroaromate OSC inhibitors
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention is concerned with novel heteroaromates, their manufacture and their use as medicaments.
BACKGROUND OF THE INVENTION
The compounds of the present invention inhibit 2,3-oxidosqualene-lanosterol cyclase (EC 5.4.99.) which is required for the biosynthesis of
Heteroaromate OSC inhibitors
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention is concerned with novel heteroaromates, their manufacture and their use as medicaments.
BACKGROUND OF THE INVENTION
The compounds of the present invention inhibit 2,3-oxidosqualene-lanosterol cyclase (EC 5.4.99.) which is required for the biosynthesis of
Dihydroindole and tetrahydroquinoline derivatives
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention is concerned with novel dihydroindole and tetrahydroquinoline derivatives, their manufacture and their use as medicaments.
BACKGROUND OF THE INVENTION
2,3-oxidosqualene-lanosterol cyclase (EC 5.4.99.) is required for the biosynthesis of cholesterol,
Dihydroindole and tetrahydroquinoline derivatives
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention is concerned with novel dihydroindole and-tetrahydroquinoline derivatives, their manufacture and their use as medicaments.
BACKGROUND OF THE INVENTION
2,3-oxidosqualene-lanosterol cyclase (EC 5.4.99.) is required for the biosynthesis of cholesterol,
Hydroxyalkylamide derivatives
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention is related to novel hydroxyalkylamide derivatives of formula (I) ##STR2##
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, W, X, m and n are as defined herein below, as well as to a process for the manufacture of a compound of formula (I), a pharmaceutical
Method of treatment with prodrugs of 6-cyclohexyl-1-hydroxy-4-methylpyridin in-2-1H-one and derivatives thereof
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND
The molecule 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, also known as Ciclopirox, is a commercially available topical antifungal agent. Ciclopirox has been used to treat superficial mycoses and Tinea versicolor. However, ciclopirox has a very poor solubility in aqueous fluids,
Prodrugs of 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-(1H)-one and derivatives thereof
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND
The molecule 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, also known as Ciclopirox, is a commercially available topical antifungal agent. Ciclopirox has been used to treat superficial mycoses and Tinea versicolor. However, ciclopirox has a very poor solubility in aqueous fluids,
Aminoalkylamide substituted cyclohexyl derivatives
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention is concerned with novel aminoalkylamide substituted cyclohexyl derivatives, their manufacture and their use as medicaments. In particular, the invention relates to compounds of the formula I
##STR00002## wherein
Analine derivatives as OSC inhibitors
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention is concerned with novel aniline derivatives, their manufacture and their use as medicaments. The compounds of the present invention inhibit 2,3-oxidosqualene-lanosterol cyclase (EC5.4.99.) which is required for the biosynthesis of cholesterol, ergosterol
Methods of forming ciclopirox or derivatives thereof in a subject by administration of prodrug
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND
The molecule 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, also known as Ciclopirox, is a commercially available antifungal agent as an olamine salt. Ciclopirox olamine has been used to treat superficial mycoses and Tinea versicolor following topical application to the skin. Following
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