Belarusian
Albanian
Arabic
Armenian
Azerbaijani
Belarusian
Bengali
Bosnian
Catalan
Czech
Danish
Deutsch
Dutch
English
Estonian
Finnish
Français
Greek
Haitian Creole
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Irish
Italian
Japanese
Korean
Latvian
Lithuanian
Macedonian
Mongolian
Norwegian
Persian
Polish
Portuguese
Romanian
Russian
Serbian
Slovak
Slovenian
Spanish
Swahili
Swedish
Turkish
Ukrainian
Vietnamese
Български
中文(简体)
中文(繁體)
phosphodiesterase/necrosis
Спасылка захоўваецца ў буферы абмену
Старонка 1 ад 48 вынікі
Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF)
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
This invention relates to novel indazole analogs. The compounds are selective inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF), and as such are useful in the treatment of asthma, arthritis, bronchitis, chronic obstructive airway disease, psoriasis,
1-Alkoxy-2-(alkoxy- or cycloalkoxy-)-4-(cyclothioalkyl- or cyclothioalkenyl-) benzenes as inhibitors of cyclic AMP phosphodiesterase and tumor necrosis factor
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
This application is a 371 of PCT/GB93/00445, filed on Mar. 4, 1993.
FIELD OF THE INVENTION
This invention is directed to sulfur-containing aromatic compounds which are useful in inhibiting cyclic AMP phosphodiesterase or tumor necrosis factor. The invention is also directed to the preparation of
Substituted pyrido[2,3-c]pyridazin-4(1H)-ones as tumor necrosis factor alpha and phosphodiesterase 4 inhibitors
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
TECHNICAL FIELD
The present invention relates to field of medical technology, specifically relates to a pyridino-oxopyridazine derivative, its pharmaceutically acceptable salts, its stereoisomers or its solvates, their preparation methods, a pharmaceutical composition comprising the compound, and
Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-.alpha., and IL-4
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention relates to a novel thiazole compound. The present invention further relates to a pharmaceutical composition comprising the thiazole compound.
BACKGROUND OF THE INVENTION
Researchers have recently discovered that cyclic adenosine 3',5'-monophosphate
Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF INVENTION
The present invention relates to novel compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
BACKGROUND OF THE INVENTION
Bronchial asthma is
Methods, articles and compositions for the pharmacologic inhibition of bone resorption with phosphodiesterase inhibitors
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The invention pertains to methods of administering active agents to inhibit unwanted bone resorption, and pharmaceutical compositions and articles containing such active agents.
BACKGROUND OF THE INVENTION
The unwanted loosening of orthopaedic implants of all types, including
Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND OF THE INVENTION
This invention relates to tricyclic 5,6-dihydro-9H-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines which are selective inhibitors of phosphodiesterase (PDE) type IV or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of asthma,
Diebenzofuran derivatives as inhibitors of PDE-4 and PDE-10
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
This application claims priority to Indian patent application No. 1647/CHE/2006 filed on Sep. 11, 2006, the contents of which are incorporated by reference in their entirety
FIELD OF INVENTION
The present invention relates to novel heterocyclic compounds that are useful as phosphodiesterase
Quinolones and their therapeutic use
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention relates to the therapeutic use of quinolone derivatives, and to certain novel such compounds.
BACKGROUND OF THE INVENTION
Quinolone compounds are known primarily as antibacterial agents (see JP-A-05025162; U.S. Pat. No. 5,037,834; EP-A-0420069;
Immunotherapeutic nitriles
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
Succinimide and maleimide cytokine inhibitors
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
BACKGROUND OF THE INVENTION
The present invention relates to a method of reducing levels of TNF.alpha. and inhibiting phosphodiesterase in a mammal and to compounds and compositions useful therein.
TNF.alpha., or minor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear
Method for treating congestive heart failure
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention relates to novel methods for treating congestive heart failure ("CHF") in mammals, especially humans, with a compound which inhibits phosphodiesterase ("PDE") type IV and the production of tumor necrosis factor ("TNF") and particularly, to such methods
Quinolones and their therapeutic use
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF THE INVENTION
The present invention relates to the therapeutic use of quinolone derivatives, and to certain novel such compounds.
BACKGROUND OF THE INVENTION
Quinolone compounds are known primarily as antibacterial agents (see JP-A-05025162; U.S. Pat. No. 5037834; EP-A-0420069;
1,4,4-(trisubstituted)cyclohexane monomers and related compounds
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
FIELD OF INVENTION
The present invention relates to novel 1,4,4-(trisubstituted)cyclohexane monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor
Benzoylpyridazines
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
This application a 371 of PCT/EP99/08047, filed Oct. 23, 1999.
The invention relates to benzoylpyridazine derivatives of the formula I ##STR1##
in which
R.sup.1, R.sup.2 in each case independently of one another are --OH, OR.sup.5, --S--R.sup.5, --SO--R.sup.5, --SO.sub.2 --R.sup.5 or Hal,
R.sup.1
Самая поўная база дадзеных пра лекавыя травы, падтрыманая навукай
- Працуе на 55 мовах
- Лячэнне травой пры падтрымцы навукі
- Распазнаванне траў па малюнку
- Інтэрактыўная GPS-карта - пазначце травы па месцы (хутка)
- Чытайце навуковыя публікацыі, звязаныя з вашым пошукам
- Шукайце лекавыя зёлкі па іх уздзеянні
- Арганізуйце свае інтарэсы і будзьце ў курсе навінавых даследаванняў, клінічных выпрабаванняў і патэнтаў
Увядзіце сімптом альбо захворванне і прачытайце пра зёлкі, якія могуць дапамагчы, набярыце траву і паглядзіце хваробы і сімптомы, супраць якіх яна выкарыстоўваецца.
* Уся інфармацыя заснавана на апублікаваных навуковых даследаваннях
