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A significant area in the field of medical informatics is concerned with the learning of medical models from low-level data. The goals of inducing models from data are twofold: analysis of the structure of the models so as to gain new insight into the unknown phenomena, and development of
Chronic obesity is a known risk factor for metabolic syndrome. However, little is known about pathological changes in the small intestine associated with chronic obesity. This study investigated cellular and subcellular level changes in the small intestine of obese mice. In this study, a mouse model
This paper aims to investigate possible application of the rough set approach to table-organized data in the medical domain, which reveals some relationships among sagittal abdominal diameter, anthropometric parameters and cardiovascular risk factors. When applied to table-organized data, the
A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed on the visceral surface of the left lateral lobe. Light microscopy demonstrated clear demarcation from the compressed adjacent parenchyma,
In a Pacific island (Polynesian) population exposed to Westernized food-stuffs and sedentary life during adulthood, the fat cell size in the gluteal region in obese men was 71% higher than in age-matched nonobese controls. Rough estimations of body fat from anthropometric measurements suggest that
Morphological changes of pancreatic B cells were investigated in ventromedial hypothalamic (VMH)-lesioned obese rats. An increase in body weight, a decrease in body length, and a marked increase in fat-pad were observed in VMH-lesioned obese rats. The volume density of pancreatic islets and that of
Liver pseudocholinesterase (PChE) activity was significantly higher in genetically obese (ob/ob) mice than in lean littermates as early as 23 days after birth. By cytochemical electron microscopy, increased staining for PChE was observed in the rough endoplasmic reticulum of ob/ob mice. Albino mice
Pancreatic β-cells normally produce adequate insulin to control glucose homeostasis, but in obesity-related diabetes, there is a presumed deficit in insulin production and secretory capacity. In this study, insulin production was assessed directly in obese diabetic mouse models, and proinsulin
It has been considered that hyperinsulinemia is one of the important factors in the development of obesity. With the purpose of investigating the mechanisms of hyperinsulinemia in obese rats induced by hypothalamic lesions (HTL), the time-caused changes in body weight, blood glucose and plasma
The private and social costs of obesity have many causes, and their consequences can be grimly predicted with only rough accuracy. Among the most devastating is the increased incidence of diabetes, of which 60% can be directly attributed to weight gain. There are now about one billion people
The increasing prevalence rates of overweight and obesity in prosperous areas of the world are causing concern everywhere. Evidence is now available on the excess mortality caused by overweight and obesity. However, in all populations, including that in Asia, the body mass index (BMI) associated
The pancreatic islets of female non-obese diabetic (NOD) mice (a model of insulin-dependent diabetes mellitus), have been examined by both light and electron microscopy. At about the age of 2 weeks, mononuclear cells began to infiltrate in or near the islets and some of these cells were in contact
Overweight, obesity and the conditions resulting from them have become one of the major challenges for health systems all over the world. High dropout rates are particularly common among the participants in outpatient obesity intervention programmes (OIP). Limited research has examined BACKGROUND
The positive effects of behavioural treatment and weight management in adolescents with severe obesity are modest. Obesity surgery can be an option for adolescents, but is not the first-hand choice of treatment. The knowledge about adolescents' own experiences of having undergone surgery
The onset of obesity-linked type 2 diabetes (T2D) is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to obesity. However, in a commonly used model of T2D, the db/db