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The transplantation of encapsulated islets of Langerhans is one approach to treat type 1 diabetes without the need of lifelong immunosuppression. Capillaries have been used for macroencapsulation because they have a favorable surface-to-volume ratio and because they can be refilled. It is unclear at
The transplantation of encapsulated islets of Langerhans is one approach to treat type 1 diabetes without the need of lifelong immunosuppression. Capillaries have been used for macroencapsulation because they have a favorable surface-to-volume ratio and because they can be refilled. It is unclear at
During development, cells may adjust their size to balance between the tissue metabolic demand and the oxygen and resource supply: Small cells may effectively absorb oxygen and nutrients, but the relatively large area of the plasma membrane requires costly maintenance. Consequently, warm and hypoxic
Terrestrial isopods have evolved pleopodal lungs that provide access to the rich aerial supply of oxygen. However, isopods occupy conditions with wide and unpredictable thermal and oxygen gradients, suggesting that they might have evolved adaptive developmental plasticity in their respiratory organs
The present morphometric and electron microscopic study follows the development of the hilar intrapulmonary artery of rat form 12 hours to 36 days of age and its structural adaptation to hypobaric hypoxia (380 torr) when exposed for periods of 3, 7, 14, and 28 days starting at 8 days of age. In
The effects of l-3-n-butylphthalide(l-NBP) and d-3-n-butylphthalide(d-NBP) on hypoxia/hypoglycemia-induced cytotoxicity in primary cultured rat cortical neurons were studied. l-NBP and d-NBP(1-100 mumol.L-1) were shown to inhibit hypoxia/hypoglycemia-induced LDH release, decrease the percent of cell
The ultrastructural alterations in CA3 pyramidal neurons induced by the irreversible organophosphorus anticholinesterase (OP anti-ChE) pinacolyl methylphosphonofluoridate (soman) and by hypoxia were examined in rat hippocampal slices. During the first 60 min of incubation in control saline, up to
The effects of hypoxia on phenotype modulation of pulmonary artery smooth muscle cells (PASMC) was observed using cell culture and morphometry analysis. The results showed that the number of diploid cells and alpha-sm-actin of the hypoxic endothelial cell condition medium group (HECCM) was lower and
Somatotropic cells from three months old male mice, made hypoxic by either bleeding or exposure to 0.5 atm. barometric pressure in a decompression chamber, showed important ultrastructural changes when compared with normoxic controls, during the 36 hours that follow initiation of hypoxia. These
Previously we have reported that association of cigarette smoke (CS) and chronic hypoxia (CH) interact positively to physiopathologically remodel pulmonary circulation. In present study we have exposed guinea pigs to CS smoke (four cigarettes/day; 3 months; CS) and to chronic hypoxia (12% O(2), 15
We placed pregnant rats in 10% O2 on the last day of gestation for less than or equal to 9 h plus 1-2 h (with their pups) after the onset of delivery. In the pups this brief perinatal hypoxia led to an altered cellular composition of the bronchiolar epithelium that persisted at least to age 30 days;
BACKGROUND
The therapeutic efficacy of human mesenchymal stem cells (hMSCs) for the treatment of hypoxic-ischemic diseases is closely related to level of hypoxia in the damaged tissues. To elucidate the potential therapeutic applications and limitations of hMSCs derived from human umbilical cords,
Weibel-Palade bodies (WPB) are endothelial vesicles that store von Willebrand factor (vWF), involved in the early phase of hemostasis. In the present study we investigated the morphodynamics of single WPB plasma membrane fusion events upon hypoxic stimulation by using atomic force microscopy (AFM).
The present study was carried out in order to determine pathogenetic mechanisms of the human minimal brain dysfunction syndrome caused by perinatal hypoxic states. In our animal model newborn rats were exposed to an hypobaric atmosphere for 10 hours daily during the first ten postnatal days, thus