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We present the case of a patient who sought treatment for fever and a maculopapular rash involving the trunk, limbs, palms and soles. The patient also presented with hepatomegaly and elevated levels of liver enzymes (with a higher increase of alkaline phosphatase). With the proposal of early
Sonography revealed multiple echo-poor lesions in the liver of a 51-year-old man with nonspecific symptoms (fatigue, drop in performance, pressure sensation in the upper abdomen), increased blood sedimentation rate (68/110 mm) and evidence of cholestasis (gamma-GT 126 U/l, alkaline phosphatase 444
The aim of the paper is to analyse the prevalence of liver involvement and related factors in HIV-infected patients with early syphilis (<2 years). Liver involvement was defined as an elevation above normal ranges of alanine transaminase, aspartate aminotransferase, gamma-glutamyltransferase and/or
METHODS
A 44-year-old heterosexual man reported having been jaundiced for 4 days. He drank little alcohol. There was no history of venereal disease.
METHODS
Laboratory tests indicated marked cholestasis (alkaline phosphatase 1589 U/I, gamma-GT 449 U/I), but only moderately raised transaminases (GOT
To investigate the prevalence of syphilitic hepatitis among a group of HIV-infected patients we performed a cross-sectional observational study of consecutive HIV-infected patients with early syphilis attending University Hospital Birmingham between 1 January 2005 and 31 August 2008. The AIDS
Biologic hepatitis is common in secondary syphilis. Six cases are reported, in which stereotyped biologic changes were found. These consisted of very high alkaline phosphatase levels and gamma GT levels, with definite inflammation. Cytolysis was moderate or absent. Diagnosis can be established when
The results of biochemical assessment of liver function are reported in 18 patients with secondary syphilis. In 9 of the patients, enzyme abnormalities were found and the most consistant abnormality was an elevated alkaline phosphatase. Six of the patients had a liver biopsy before treatment and the
Hepatitis is an uncommon manifestation of early acquired syphilis. A case of secondary syphilis presenting with jaundice and papular eruption is reported. The icterus was slight and responded romptly to penicillin therapy, transaminase levels were moderately increased. Alkaline phosphatase was
Hepatic involvement in a patient with secondary syphilis was documented by demonstrating spirochetes in the portal tracts. Raised alkaline phosphatase levels in early hepatic syphilis may be explained by involvement of bile ducts and vascular structures.
The enzymatic changes in tertiary nasal syphilis were studied in 5 patients. The cholinesterase was increased in the subepithelium, around the glands and blood vessels, denoting parasympathetic hyperactivity. Acid phosphatase was increased in the epithelium, stromal histiocytes, around the glands
Atypical manifestations of early syphilis, although uncommon, may represent diagnostic difficulties and delay therapy. We describe two cases of hepatitis complicating early syphilis. Clues to the diagnosis of early syphilitic hepatitis include the presence of perianal lesions and disproportionate
METHODS
There has been a recent, dramatic increase in the incidence of congenital syphilis, particularly in urban areas. We describe seven infants seen during one year who were first given a diagnosis of congenital syphilis at 3 to 14 weeks of age, when symptoms developed. We reviewed these infants'
A 36-year old man with known HIV infection presented to an outpatient genitourinary service with jaundice, rash and sore throat. Investigations revealed marked biochemical abnormalities, including alkaline phosphatase and alanine transaminase >10 times the upper limit of normal. Liver ultrasound was