Effect of Herbs and Spices on Metabolic Regulation and Appetite in Healthy Subjects
Ключови думи
Резюме
Описание
The aims of the study is to investigate whether consumption of preload isovolumetric (220 ml) spice-based beverages contained total polyphenol concentration to 185 mg gallic-acid equivalents followed by white wheat bread challenge (contained 50 g available carbohydrate) might affect postprandial glucose metabolism, inflammatory markers, appetite-related gut hormones, plasma antioxidant capacity, as well as appetite sensations in healthy subjects.
Дати
| Последна проверка: | 07/31/2018 |
| Първо изпратено: | 01/09/2014 |
| Очаквано записване подадено: | 01/09/2014 |
| Първо публикувано: | 01/13/2014 |
| Изпратена последна актуализация: | 08/22/2018 |
| Последна актуализация публикувана: | 08/26/2018 |
| Действителна начална дата на проучването: | 02/28/2014 |
| Приблизителна дата на първично завършване: | 05/31/2014 |
| Очаквана дата на завършване на проучването: | 05/31/2014 |
Състояние или заболяване
Интервенция / лечение
Dietary Supplement: Spices 1
Dietary Supplement: Spices 2
Dietary Supplement: Spices 3
Dietary Supplement: Herbs 1
Dietary Supplement: Herbs 2
Dietary Supplement: Placebo
Фаза
Групи за ръце
| Arm | Интервенция / лечение |
|---|---|
| Experimental: Spices 1 220 ml test drink containing spices 1, acute study / one time administration | Dietary Supplement: Spices 1 In this study, subjects are asked to consume 200 ml beverage drinks contain certain amounts of spices 1. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate. |
| Experimental: Spices 2 220 ml test drink containing spices 2, acute study / one time administration | Dietary Supplement: Spices 2 In this study, subjects are asked to consume 200 ml beverage drinks contain certain amounts of spices 2. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate. |
| Experimental: Spices 3 220 ml test drink containing spices 3, acute study / one time administration | Dietary Supplement: Spices 3 In this study, subjects are asked to consume 200 ml beverage drinks contain certain amounts of spices 3. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate. |
| Experimental: Herbs 1 220 ml test drink containing herbs 1, acute study / one time administration | Dietary Supplement: Herbs 1 In this study, subjects are asked to consume 200 ml beverage drinks contain certain amounts of herbs 1. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate. |
| Experimental: Herbs 2 220 ml test drink containing herbs 2, acute study / one time administration | Dietary Supplement: Herbs 2 In this study, subjects are asked to consume 200 ml beverage drinks contain certain amounts of herbs 2. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate. |
| Placebo Comparator: Placebo 220 ml control drink, acute study / one time administration | Dietary Supplement: Placebo As a control, subjects are asked to consume 200 ml control drinks. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate. |
Критерии за допустимост
| Възрасти, отговарящи на условията за проучване | 18 Years Да се 18 Years |
| Полове, допустими за проучване | All |
| Приема здрави доброволци | Да |
| Критерии | Inclusion Criteria: - Healthy males and females - Signed informed consent - BMI 20 - 28 kg/m2 with weight change <3 kg latest 2 months) - Must be able to accept herbs and spices Exclusion Criteria: - Below 18 years - Uncomfortable speaking English and/or difficulties in understanding spoken English - Smoking or using snuff - Vegetarian or vegan - Stressed by venous blood sampling or previous experience of being difficult to cannulate - Receiving any drug treatment that may influence the study outcomes - Pregnancy or breastfeeding |
Резултат
Първични изходни мерки
1. Changing on blood glucose concentration after treatment with herbs and spices [Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min.]
Вторични изходни мерки
1. Changing on subjective appetite ratings after treatment with herbs and spices [Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min.]
2. Changing on metabolic biomarkers after treatment with herbs and spices [Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min.]
3. Changing on urine metabolite profile after treatment with herbs and spices [Prior to the initial intervention at 0 min and up to 24-h after intervention]
4. Changing on plasma metabolite profile after treatment with herbs and spices [Prior to the initial intervention at 0 min and after intervention at 60, 90, 120, 180 min.]
