Correlation Between Sex Hormones, Insulin Resistance and Depression in Response to Exercises in Postmenopausal
Ключови думи
Резюме
Описание
It is an interventional study in which 60 women estimated to enroll according to random allocation and assigned into two groups equal. The study group will receive aerobic exercises in addition to diet recommendations while the control group will receive diet recommendations. the aerobic exercises in form of treadmill training intensity of exercises high intensity, target heart rate (THR) will be 70-80% of heart maximum (HR MAX)time of session 40 min initial 10 min warm up exercises on treadmill in low intensity and active phase 20- 30 min intensity will increase until patient reach to THR then intensity decrease until session will be ended by cooling down phase for 10 min . The volunteers will perform exercises 3 times per week for 12 weeks .insulin resistance will be measured by HOMA -IR index and sex hormones (estradiol ,testosterone. sex hormone binding globin ) pre and post intervention and use zung self-rating depression scale to assess depression
Дати
| Последна проверка: | 06/30/2020 |
| Първо изпратено: | 07/07/2020 |
| Очаквано записване подадено: | 07/09/2020 |
| Първо публикувано: | 07/14/2020 |
| Изпратена последна актуализация: | 07/09/2020 |
| Последна актуализация публикувана: | 07/14/2020 |
| Действителна начална дата на проучването: | 06/30/2020 |
| Приблизителна дата на първично завършване: | 11/30/2020 |
| Очаквана дата на завършване на проучването: | 12/14/2020 |
Състояние или заболяване
Интервенция / лечение
Other: study group will receive aerobic exercises and diet
Other: diet recommendations
Фаза
Групи за ръце
| Arm | Интервенция / лечение |
|---|---|
| Other: study group will receive aerobic exercises and diet The study group will receive aerobic exercises in addition to diet recommendations while . the aerobic exercises in form of treadmill training intensity of exercises high intensity, target heart rate (THR) will be70-80% of heart maximum (HR MAX)time of session 40 min initial 10 min warm up exercises on treadmill in low intensity and active phase20- 30 min intensity will increase until patient reach to THR then intensity decrease until session will be ended by cooling down phase for 10 min . The volunteers will perform exercises 3 times per week for 12 weeks | Other: study group will receive aerobic exercises and diet It is an interventional study in which 60 women estimated to enroll according to random allocation and assigned into two groups equal. The study group will receive aerobic exercises in addition to diet recommendations . the aerobic exercises in form of treadmill training intensity of exercises high intensity, target heart rate (THR) will be70-80% of heart maximum (HR MAX)time of session 40 min initial 10 min warm up exercises on treadmill in low intensity and active phase20- 30 min intensity will increase until patient reach to THR then intensity decrease until session will be ended by cooling down phase for 10 min . The volunteers will perform exercises 3 times per week for 12 weeks .insulin resistance will be measured by homeostasis model assessment (HOMA) index of insulin-resistance (HOMA -IR) index and sex hormones (estradiol ,testosterone. sex hormone binding globin ) pre and post intervention and use zung self-rating depression scale to assess depression |
| Other: diet recommendations the control group will receive diet recommendations.he volunteers will follow diet recommendations for 12 weeks |
Критерии за допустимост
| Възрасти, отговарящи на условията за проучване | 55 Years Да се 55 Years |
| Полове, допустими за проучване | Female |
| Приема здрави доброволци | Да |
| Критерии | Inclusion Criteria: - Sixty Postmenopausal women (55-65 y) - Body mass index (BMI) ranged from 35 to 39.9 kg/m2 - Postmenopausal more than 2 years Exclusion Criteria: - • women receiving weight-reduction interventions - taking lipid lowering drugs - regular medications(e.g., β-blockers, α-blockers, digoxin, diuretics, aspirin, nitrates, Presently using sex hormones) - having active chronic illness (e.g., rheumatoid arthritis, hyperthyroidism, and inflammatory bowel disease) and diabetes mellitus or other (unstable) endocrine-related diseases - cognitive impairment that will make it difficult to partake in the study - presence of malignant disease - blood donation within the last 30 days - Participation as a subject in any type of study or research during the prior 90 days - smoking |
Резултат
Първични изходни мерки
1. insulin resistance [12 weeks]
2. sex hormones [12 weeks]
