Effect of Propolis Application on Burn Healing
Ключови думи
Резюме
Дати
Последна проверка: | 01/31/2020 |
Първо изпратено: | 02/16/2020 |
Очаквано записване подадено: | 02/17/2020 |
Първо публикувано: | 02/19/2020 |
Изпратена последна актуализация: | 06/29/2020 |
Последна актуализация публикувана: | 07/01/2020 |
Действителна начална дата на проучването: | 08/31/2020 |
Приблизителна дата на първично завършване: | 09/30/2020 |
Очаквана дата на завършване на проучването: | 12/31/2020 |
Състояние или заболяване
Интервенция / лечение
Biological: burn wound dressing
Фаза
Групи за ръце
Arm | Интервенция / лечение |
---|---|
Placebo Comparator: Control group It will be accepted as the control group and 4 experimental burn wounds will be created on the back of the rats in the group and no treatment will be given. | |
Active Comparator: 1% Silver Sulfadiazine 4 experimental burn wounds will be created on the back of the rats in the group and dressing with 1% Silver Sulfadiazine will be done on the back of the rats every day for 21 days. | |
Active Comparator: %0.2 Nitrafurozon 4 experimental burn wounds will be created on the back of the rats in the group and dressing with %0.2 Nitrafurozon will be done on the back of the rats every day for 21 days. | |
Experimental: 10% Propolis 4 experimental burn wounds will be created on the back of the rats in the group and dressing with 10% Propolis will be done on the back of the rats every day for 21 days. | |
Experimental: 15% Propolis 4 experimental burn wounds will be created on the back of the rats in the group and dressing with 15% Propolis will be done on the back of the rats every day for 21 days. | |
Active Comparator: Propolis vehicle 4 experimental burn wounds will be created on the back of the rats in the group and dressing with Propolis vehicle will be done on the back of the rats every day for 21 days. |
Критерии за допустимост
Възрасти, отговарящи на условията за проучване | 8 Weeks Да се 8 Weeks |
Полове, допустими за проучване | All |
Приема здрави доброволци | Да |
Критерии | Inclusion Criteria: - adult (8-12 weeks) - 200-300 grams - Wistar-Albino rat - with 4 second-degree superficial contact burn are at its back. Exclusion Criteria: - the death of the rat in the research process |
Резултат
Първични изходни мерки
1. tumour necrosis factor-alpha, [3rd days]
2. tumour necrosis factor-alpha, [7th days]
3. interleukin-1β [3rd days]
4. interleukin-1β [7th days]
5. superoxide dismutase [3rd days]
6. superoxide dismutase [7th days]
7. malondialdehyde [3rd days]
8. malondialdehyde [7th days]
9. myeloperoxidase [3rd days]
10. myeloperoxidase [7th days]
11. hydroxyproline [14th days]
12. hydroxyproline [21st days]
13. Masson trichrome [14th days]
14. Masson trichrome [21st days]
Вторични изходни мерки
1. wound size [21 days]
2. bulla [3rd, 7th, 14th and 21st days]
3. erythema [3rd, 7th, 14th and 21st days]
4. edema [3rd, 7th, 14th and 21st days]
5. inflammatory cell infiltration [3rd, 7th, 14th and 21st days]
6. necrosis [3rd, 7th, 14th and 21st days]
7. ulceration [3rd, 7th, 14th and 21st days]
8. angiogenesis [3rd, 7th, 14th and 21st days]
9. neovascularization [3rd, 7th, 14th and 21st days]
10. fibroblast proliferation [3rd, 7th, 14th and 21st days]
11. epithelization [3rd, 7th, 14th and 21st days]
12. umber of hair follicles [3rd, 7th, 14th and 21st days]
13. damage of skin attachments [3rd, 7th, 14th and 21st days]