Effects of Training and Detraining on Postmenopausal Breast Cancer Survivors
Ключови думи
Резюме
Описание
The present study aimed to verify the effects of 12 weeks of resistance exercise training and successive 12 weeks of detraining on body composition (Body Mass, Body Mass Index, Fat Mass, and Fat-Free Mass), lipid profile (Triglycerides, Total Cholesterol, LDL-Cholesterol, HDL-Cholesterol), muscle strength (1RM test), oxidative stress (Thiobarbituric acid reactive substances,Non-Protein Thiols, Catalase activity, and Superoxide Dismutase), and inflammatory markers (Interferon γ, Tumor Necrosis Factor α, interleukin 6 , Adiponectin, and Interleukin 4) of postmenopausal breast cancer survivors undergoing tamoxifen treatment.
Дати
Последна проверка: | 06/30/2020 |
Първо изпратено: | 07/15/2020 |
Очаквано записване подадено: | 07/15/2020 |
Първо публикувано: | 07/20/2020 |
Изпратена последна актуализация: | 07/15/2020 |
Последна актуализация публикувана: | 07/20/2020 |
Действителна начална дата на проучването: | 06/30/2016 |
Приблизителна дата на първично завършване: | 07/30/2017 |
Очаквана дата на завършване на проучването: | 06/29/2018 |
Състояние или заболяване
Интервенция / лечение
Other: Exercise training
Other: Exercise training
Фаза
Групи за ръце
Arm | Интервенция / лечение |
---|---|
Experimental: Exercise training Postmenopausal breast cancer survivors undergoing tamoxifen treatment, who will do the evaluations before the beginning and after 12 weeks of exercise training and subsequently 12 weeks of detraining. | Other: Exercise training The exercise training program will last 12 weeks, with a frequency of three sessions per week, held on Mondays, Wednesdays, and Fridays. Each session will last approximately 50 minutes. Whenever the maximum number of pre-established repetitions is successfully performed, the intensity will be increased by 5 to 10%. All sessions will be supervised by trained professionals. |
Критерии за допустимост
Възрасти, отговарящи на условията за проучване | 40 Years Да се 40 Years |
Полове, допустими за проучване | Female |
Приема здрави доброволци | Да |
Критерии | Inclusion Criteria: - 1) age between 40 and 65 years; 2) stage 0-IIIA Breast Cancer; 3) submission to axillary lymphadenectomy); 4) completion of chemotherapy and radiation therapy at least 6 months before the study; 5) lack of participation in supervised physical exercise programs in the six months before the beginning of the research; 6) absence of a problem and/or musculoskeletal limitation that would prevent the performance of the proposed exercises; 7) release by a medical professional to participate in the physical training program; 8) residency in Uberlândia Exclusion Criteria: - missing more than 20% of the exercise sessions; unable to perform the proposed training protocols; change in drug therapy during the intervention. |
Резултат
Първични изходни мерки
1. Changes in blood biomarkers (pg/mL) [Before and within 72 hours after 12 weeks of exercise training/detraining]
2. Changes in blood biomarkers (mmol/L) [Before and within 72 hours after 12 weeks of exercise training/detraining]
3. Changes in blood biomarkers (K/gHb.s) [Before and within 72 hours after 12 weeks of exercise training/detraining]
4. Changes in blood biomarkers (U/gHb) [Before and within 72 hours after 12 weeks of exercise training/detraining]
5. Changes in blood biomarkers (mg/dL) [Before and within 72 hours after 12 weeks of exercise training/detraining]
Вторични изходни мерки
1. Strength (kg) [Before and within 72 hours after 12 weeks of exercise training/detraining]
2. Anthropometry (kg) [Before and within 72 hours after 12 weeks of exercise training/detraining]
3. Anthropometry (%) [Before and within 72 hours after 12 weeks of exercise training/detraining]
4. Anthropometry (kg/m²) [Before and within 72 hours after 12 weeks of exercise training/detraining]