The Effects of Rhus Coriaria L. on Serum Uric Acid Levels
Ключови думи
Резюме
Описание
Rhus coriaria L.(Rhus) is a well-known spice widely consumed in the world which has also been utilized extensively for medicinal purposes. The antioxidant components of this plant made it a favorable target for laboratory and animal studies in different conditions such as oxidative stress cytotoxicity, diabetes and hyperlipidemia. Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrheic, antiseptic, anorexic and antihyperglycemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.
Uric acid (UA; 7,9-dihydro-1H-purine-2,6,8(3H)-trione) has been implicated as a risk factor and cause of numerous disease states. Some disease states, such as gout, hypertension, and cardiovascular disease, have been shown to result when UA levels in the blood are too high. Hyperuricemia predicts the development of hypertension in the general population, and an independent positive correlation between UA levels and the occurrence of hypertension has been reported. Hyperuricemia may also be a risk factor for cardiovascular disease, myocardial infarction, and stroke.
The manipulation of serum UA levels has become a popular strategy in the treatment of a variety of diseases. This is either accomplished through dietary and lifestyle changes or through treatment with UA reducing drugs.
The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on serum uric acid levels.
Дати
| Последна проверка: | 03/31/2019 |
| Първо изпратено: | 08/30/2016 |
| Очаквано записване подадено: | 08/30/2016 |
| Първо публикувано: | 09/06/2016 |
| Изпратена последна актуализация: | 04/03/2019 |
| Последна актуализация публикувана: | 04/07/2019 |
| Действителна начална дата на проучването: | 05/31/2019 |
| Приблизителна дата на първично завършване: | 10/31/2019 |
| Очаквана дата на завършване на проучването: | 11/30/2019 |
Състояние или заболяване
Интервенция / лечение
Drug: Rhus (Somagh)
Drug: Placebo
Фаза
Групи за ръце
| Arm | Интервенция / лечение |
|---|---|
| Active Comparator: Rhus (Somagh) 500 mg twice daily after meal for 6 weeks | Drug: Rhus (Somagh) 500 mg twice daily after meal for 6 weeks |
| Placebo Comparator: Placebo 500 mg twice daily after meal for 6 weeks | Drug: Placebo 500 mg twice daily after meal for 6 weeks |
Критерии за допустимост
| Възрасти, отговарящи на условията за проучване | 20 Years Да се 20 Years |
| Полове, допустими за проучване | All |
| Приема здрави доброволци | Да |
| Критерии | Inclusion Criteria: - Healthy individuals Exclusion Criteria: - Serum uric acid levels that need medical treatment - Gout - Diabetes mellitus - Hypo. or hyperthyroidism - Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure - Use of drugs: Uric acid lowering agents - Pregnancy - Lactation - History of allergic reaction to Somagh |
Резултат
Първични изходни мерки
1. serum uric acid levels [6 weeks]
Вторични изходни мерки
1. Number of patients with adverse events. [6 weeks]
