DNA-templated porous nanoplatform towards programmed "double-hit" cancer therapy via hyperthermia and immunogenicity activation.

Photothermal therapy, assisted with long-term immunological anti-tumor effect, has great potential in clinical medical practice. Herein, a brand new DNA-template hydrothermal method was developed to prepare novel Co₉S₈ nanoplatform with outstanding hydrophily and mesoporous internal structure. Based on the mesoporous Co₉S₈ nanoplatform, MRI-guided enhanced photothermal-immunology "double-hit" synergistic cancer therapy was achieved, through the HSP90 inhibition and immunology activation effect of the loaded epigallocatechin gallate and oxaliplatin. It is noteworthy that the drugs were stepwise released from the nanoplatform under the trigger of pH and heat, respectively. More importantly, the high efficient synergistic cancer therapy and long-term immunological anti-tumor effect were confirmed in vivo. The developed porous nanoplatform, taking accounts of both high efficient tumor ablation and long-term anti-tumor effect, provide a new strategy to the development of next generation nanomedicine for clinical cancer treatment.