Indian Journal of Otolaryngology and Head and Neck Surgery 2009-Dec
Effects of radiotherapy on parotid salivary sialochemistry in head and neck cancer patients.
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OBJECTIVE
To determine the effects of high dose irradiation on parotid salivary sodium and pH concentration at subsequent duration of 1.5, 3 and 6 months following radiotherapy.
METHODS
Eighty parotid glands of head and neck cancer patients were irradiated with mean dose of 66 Gy. The stimulated parotid flow (PF) was collected by a cannulation of Stenson's duct followed by analysis of sodium (PF sodium) by Easylyte Sodium/Potassium auto analyzer and pH by litmus narrow band pH paper.
RESULTS
A steep elevation of PF sodium was found in post-RT period after 1.5 months of starting RT followed by gradual increase up to 6 months and pH changed towards acidity.
CONCLUSIONS
A high dose of 66 Gy causes irreversible damage to parotid salivary duct system.
