Evaluation of bioartificial pancreas function made from sodium alginate and poly-L-lisine microcapsules settled with viable pancreatic islets.

The possibility of transplantation of immuno-isolated viable pancreatic islets is a promising alternative for treatment diabetic patients. To establish the value of the artificial prosthesis made from settled with viable pancreatic islets microcapsulated using sodium alginate and poly-L-lisine, the glucose plasma levels were analyzed versus time after implantation into peritoneal cavity of rats or mice with alloxan-induced diabetes. The proper function of the bio-artificial pancreas manifested in normalization of glucose plasma level has been observed from 14 to 21 days after implantation in diabetic mice and rats.