[Fatty acid of human plasma under the influence of acute strong normobaric hypoxia].

The influence of acute normobaric hypoxia on total pool of human plasma fatty acids was studied in experiment (respiration of hypoxic gas mixture containing 8% of O2, during 25 min). Health status of participants-volunteers and the hypoxia intensity were monitored with a complex of electrophysiological methods: EEC, ECG, measurement of blood pressure, SpO2, evaluation of cardiac output, gas analysis of exhaled air. Using gas chromatography we studied plasma fatty acids total profile (esterificated and non-esterificated) before hypoxia exposure, on 2nd, 5th, 10th, 20th minutes of acute hypoxia and on 5th and 15th minutes of recovery. It was shown that blood saturation value dropped to 52.1 +/- 7.1 % on 25th minute of hypoxia exposure. There were no statistically significant changes in concentrations of total fatty acids, saturated fatty acids, monounsaturated palmitoleic acid, polyunsaturated linoleic and linolenic acids. Significant (p < 0.05) decrease of concentration of oleic and arachidonic acids was displayed that persisted after 15 minutes of recovery period. It is possible to assume that these changes in unsaturated fatty acid concentration were caused by activation of free radical oxidation processes and production of oleic acid derivatives. The performed hypoxic test seemed to be sufficient in order to reveal hypoxia effects on metabolism of individual unsaturated fatty acids.