Bioorganic and Medicinal Chemistry Letters 2006-May
(R)-sila-venlafaxine: a selective noradrenaline reuptake inhibitor for the treatment of emesis.
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Sila-substitution of drugs (the carbon/silicon switch) is a concept that is being successfully used for the development of new chemical entities. The (R)-sila-analogue of the antidepressant venlafaxine is devoid of the serotonin reuptake inhibition observed with the marketed drug, leading to a selective noradrenaline reuptake inhibitor displaying anti-emetic properties.