Relationship between IDH1 mutation and preoperative seizure in low-grade gliomas: A meta-analysis.
Ключови думи
Резюме
OBJECTIVE
The aim of this analysis was to perform a meta-analysis assessing the relationship between isocitrate dehydrogenase 1 (IDH1) mutation and preoperative seizure in low-grade gliomas.
METHODS
Systematic computerised searches of the PubMed and Web of Knowledge were performed. The meta-analysis of pooled odds ratio (OR) and 95% confidence interval (CI) for preoperative seizure risk stratified by IDH1 mutation status were calculated.
RESULTS
Five studies with 540 patients were included for meta-analysis. The preoperative seizure incidence ranged from 73.54% to 94.12% in the IDH1 Mutation (+) group, compared 37.50%-76.92% in the IDH1 Mutation (-) group. The pooled crude OR was 2.750 (95% CI 1.763-4.290; Z=4.46, P=0.000). The Begg's test (z=0.73, P=0.462), the Egger's test (t=0.41, P=0.708) and symmetrical funnel plot suggested no significant publication bias. Sensitivity analysis by only pooled adjusted ORs showed the pooled OR was 2.740 (95% CI 1.593-4.714; Z=3.64, P=0.000) which indicated the results were robust. Meta-regression analysis showed preoperative seizure OR was not related with preoperative seizure incidence (t=0.37, P=0.736), and not related with IDH1 mutation rate (t=1.85, P=0.162).
CONCLUSIONS
Our meta-analysis indicated that IDH1 mutation was related with preoperative seizure in low-grade gliomas.
