[The effect of internal irradiotherapy with 32P glass microspheres on tumor vasculature in mouse sarcoma 180].

In order to investigate the effect of internal irradiotherapy on tumor microvasculature, the vascular changes of tumor S180 following internal irradiotherapy with 32P glass microspheres were observed microscopically with vessel casts of resin perfusion and ink perfusion. The results showed that the microvessels expanded with the endothelial cells swelling and the amount of microvessels and new vessels decreased, which led to peritumoral vascular density descended. It suggests that internal irradiotherapy destroying the tumor microvasculature as external irradiation is an important influence on the efficiency of internal irradiotherapy.