[The mechanism(s) of alpha-(aminoethyl)-gamma-butyrolactone. In vivo studies in mice].

This paper describes the synthesis of alpha-(dimethylaminoethyl)-gamma, gamma-diphenyl-gamma-butyrolactone 4. The study of convulsions induced, on mice, by this compound could show the existence of antiGABAergic and cholinergic action components, but, unlike the homologous alpha- (dialkylaminomethil)-gamma-butyrolactones (with one -CH2- less on the aminoalkyl chain), no antiglycinergic component was detected. The effects of atropine on the aminolactone 4 induced convulsions (antagonism 5mn and synergy 30 mn after atropine) could suggest an activation of the glutamatergic receptors (NMDA), by indirect stimulation of their glycinergic site, by the aminolactone 4.