Ultrasound lipoclasia on subcutaneous adipose tissue to produce acute hyperglycemia and enhance acute inflammatory response in healthy female rats.
Ключови думи
Резюме
BACKGROUND
Ultrasound lipoclasia (USL) on white adipose tissue (WAT) has been largely used in the treatment of cellulite. Nevertheless, the acute consequences of this therapy on metabolism and biochemical profile are significant and should be taken into account.
OBJECTIVE
To analyze the acute metabolic effects of USL in WAT of healthy rats using analyses of body composition, biochemical profile, and inflammatory markers.
METHODS
Female Wistar rats weighing approximately 250 g were divided into two groups (n=10 each): control and treated. The treated group was submitted to USL, a single 3-MHz ultrasound application (5.6 W/cm(2)), in gluteal-femoral WAT (3 cm(2)) for 3 minutes. Animals were subjected to glycemic control. Body composition was analyzed using bio-impedance, and lipid profile, insulinemia, C-reactive protein (CRP), and lactate dehydrogenase (LDH) were measured.
RESULTS
USL reduced (p<.05) body fat mass. The basal metabolic rate was found to have increased (p<.05). Basal insulin and the lipoprotein profile were not different, although the glycemic curve and CRP and LDH (p<.05) levels were higher.
CONCLUSIONS
Fat mobilization using USL provokes acute hyperglycemia and enhances an acute inflammatory response, producing cardiometabolic risk in female rats.
