Journal of Stomatology, Oral and Maxillofacial Surgery 2020-Feb
Evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on post-operative pain, edema, and trismus following lower third molar removal: A randomized controlled clinical trial.
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MATERIAL AND METHODS
Patients were randomly divided into A-PRF, CGF and control groups. After extraction of the third molars, A-PRF and CGF were prepared and applied to the extraction sockets in study groups, while nothing was applied to the control group. Edema was measured from 5 reference points including tragus, labial commissure, soft tissue pogonion, lateral corner of the eye/lateral canthus and angulus mandible. Trismus measured as the distance between the right lower and upper right central incisors. Trismus and edema were measured preoperatively, and on postoperative 2nd and 7th days. Pain evaluated using the visual analogue scale (VAS) between 6th hour and 7th day after surgery.RESULTS
A total of 75 patients, 25 in each group, were included in the study. The change in tragus to labial commissure measurements showed a significant difference between baseline-7th days among control and CGF groups (P= 0.038). Significant differences observed between the tragus to pogonion measurements at baseline-7th days among the control-CGF groups (P= 0.014), and A-PRF-CGF groups (P = 0.038). Secondary outcome variables trismus, pain, and analgesic consumption showed no significant differences among the groups (P > 0.05).