ILEOCOLONIC LYMPHONODULAR HYPERPLASIA IN CHILDREN; RELATED WITH VARIETY OF ETIOLOGIES RANGING FROM FOOD HYPERSENSITIVITY TO FAMILIAL MEDITERRANEAN FEVER.

We aimed to share our experience about the demographics and clinical characteristics and outcome of lymphonodular hyperplasia (LNH) in children.The study included the children that performed colonoscopy between January 2015 and May 2018 (n=361). Demographics, treatment modalities and outcomes of the patients with LNH were recorded.LNH was found in 66 patients (18.3%, %59.1 male, mean age: 8.6 ± 5.96 years). We found that the etiologic factors of LNH was food hypersensitivity (FH) in 25 (37.8%), nonspecific colitis in 12 (18.2%), irritable bowel syndrome in 10 (15.2%), familial Mediterranean fever in seven (10.6%), primary immunodeficiency in four (6.1%) patients. Intestinal dysmotility, oxyuriasis and Giardiasis in one (1.5%) patient. Additionally, in genetic analysis of patients with idiopathic LNH (n=4), we detected heterozygote MEFV mutations in all. Cow's milk and egg (25%) were most common allergens in patients with FH. Symptoms of all patients (n=25) were improved after elimination diet.LNH is a common finding in pediatric colonoscopies with variety of etiologies ranging from FH, familial Mediterranean fever to immunodeficiencies.